The Expression and Clinical Significance of DNA Methyltransferase Proteins in Human Gastric Cancer
This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive...
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Published in | Digestive diseases and sciences Vol. 53; no. 8; pp. 2083 - 2089 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Boston
Springer US
01.08.2008
Springer Springer Nature B.V |
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Abstract | This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive rates of DNMT1, DNMT3a, and DNMT3b expression in GC tissues were 81.6%, 81.6%, and 68.4%, respectively, and they were significantly higher than those of both para-cancerous (39.5%, 50%, and 44.7%) and normal tissues (10.5%, 10.5%, and 7.9%). DNMT1 was well distributed in the cytoplasm and nuclei of tumor cells or glands, while DNMT3a and 3b were well distributed only in the cytoplasm, as shown by staining a dark brown color. A significant correlation between the DNMT1 and DNMT3a proteins (
P
< 0.01), a low correlation between DNMT3a and DNMT3b (
P
< 0.05), and no correlation between DNMT1 and DNMT3b (
P
> 0.05) were observed. DNMT1 protein expression exhibited no correlation with age, lymphnode metastasis, and also tumor differentiation, but it may have had a correlation with gender. The DNMT3 family was not associated with these factors. Therefore, DNMT overexpression is involved in gastric tumorigenesis, but there is no correlation between the DNMTs and the biological behaviors of tissues. |
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AbstractList | This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive rates of DNMT1, DNMT3a, and DNMT3b expression in GC tissues were 81.6%, 81.6%, and 68.4%, respectively, and they were significantly higher than those of both para-cancerous (39.5%, 50%, and 44.7%) and normal tissues (10.5%, 10.5%, and 7.9%). DNMT1 was well distributed in the cytoplasm and nuclei of tumor cells or glands, while DNMT3a and 3b were well distributed only in the cytoplasm, as shown by staining a dark brown color. A significant correlation between the DNMT1 and DNMT3a proteins (P < 0.01), a low correlation between DNMT3a and DNMT3b (P < 0.05), and no correlation between DNMT1 and DNMT3b (P > 0.05) were observed. DNMT1 protein expression exhibited no correlation with age, lymphnode metastasis, and also tumor differentiation, but it may have had a correlation with gender. The DNMT3 family was not associated with these factors. Therefore, DNMT overexpression is involved in gastric tumorigenesis, but there is no correlation between the DNMTs and the biological behaviors of tissues. This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive rates of DNMT1, DNMT3a, and DNMT3b expression in GC tissues were 81.6%, 81.6%, and 68.4%, respectively, and they were significantly higher than those of both para-cancerous (39.5%, 50%, and 44.7%) and normal tissues (10.5%, 10.5%, and 7.9%). DNMT1 was well distributed in the cytoplasm and nuclei of tumor cells or glands, while DNMT3a and 3b were well distributed only in the cytoplasm, as shown by staining a dark brown color. A significant correlation between the DNMT1 and DNMT3a proteins (P < 0.01), a low correlation between DNMT3a and DNMT3b (P < 0.05), and no correlation between DNMT1 and DNMT3b (P > 0.05) were observed. DNMT1 protein expression exhibited no correlation with age, lymphnode metastasis, and also tumor differentiation, but it may have had a correlation with gender. The DNMT3 family was not associated with these factors. Therefore, DNMT overexpression is involved in gastric tumorigenesis, but there is no correlation between the DNMTs and the biological behaviors of tissues. [PUBLICATION ABSTRACT] This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive rates of DNMT1, DNMT3a, and DNMT3b expression in GC tissues were 81.6%, 81.6%, and 68.4%, respectively, and they were significantly higher than those of both para-cancerous (39.5%, 50%, and 44.7%) and normal tissues (10.5%, 10.5%, and 7.9%). DNMT1 was well distributed in the cytoplasm and nuclei of tumor cells or glands, while DNMT3a and 3b were well distributed only in the cytoplasm, as shown by staining a dark brown color. A significant correlation between the DNMT1 and DNMT3a proteins ( P < 0.01), a low correlation between DNMT3a and DNMT3b ( P < 0.05), and no correlation between DNMT1 and DNMT3b ( P > 0.05) were observed. DNMT1 protein expression exhibited no correlation with age, lymphnode metastasis, and also tumor differentiation, but it may have had a correlation with gender. The DNMT3 family was not associated with these factors. Therefore, DNMT overexpression is involved in gastric tumorigenesis, but there is no correlation between the DNMTs and the biological behaviors of tissues. |
Author | Fang, Jing-Yuan Chen, Xiao-Yu Peng, Yan-Shen Ding, Wen-Jin |
Author_xml | – sequence: 1 givenname: Wen-Jin surname: Ding fullname: Ding, Wen-Jin organization: Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease, Department of Gastroenterology, Shanghai Jiao-Tong University School of Medicine Xinhua Hospital – sequence: 2 givenname: Jing-Yuan surname: Fang fullname: Fang, Jing-Yuan email: jingyuanfang@yahoo.com organization: Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease – sequence: 3 givenname: Xiao-Yu surname: Chen fullname: Chen, Xiao-Yu organization: Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease – sequence: 4 givenname: Yan-Shen surname: Peng fullname: Peng, Yan-Shen organization: Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institute of Digestive Disease |
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Keywords | Immunohistochemistry Human gastric cancer DNA methyltransferase Biological behaviors Human DNA Gastroenterology Digestive diseases Metabolic diseases Human gastric cancer .DNA methyltransferase 1.Immunohistochemistry .Biological behaviors Malignant tumor Stomach cancer Protein Cancer Gastric disease |
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PublicationTitle | Digestive diseases and sciences |
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Title | The Expression and Clinical Significance of DNA Methyltransferase Proteins in Human Gastric Cancer |
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