Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 46; no. 3; pp. 537 - 544
• Main Authors: Holze, Friederike, Vizeli, Patrick, Ley, Laura, Müller, Felix, Dolder, Patrick, Stocker, Melanie, Duthaler, Urs, Varghese, Nimmy, Eckert, Anne, Borgwardt, Stefan, Liechti, Matthias E.
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.02.2021; Springer International Publishing
• Subjects: Anxiety; Autonomic nervous system; Blood pressure; Brain-derived neurotrophic factor; Dissolution; Double-blind studies; Heart rate; Ketanserin; LSD; Lysergic acid diethylamide; Lysergide; Pharmacokinetics; Placebos; Receptor mechanisms; Serotonin S2 receptors

Growing interest has been seen in using lysergic acid diethylamide (LSD) in psychiatric research and therapy. However, no modern studies have evaluated subjective and autonomic effects of different and pharmaceutically well-defined doses of LSD. We used a double-blind, randomized, placebo-controlled...