Postmortem molecular screening in unexplained sudden death

• Published in: Journal of the American College of Cardiology Vol. 43; no. 9; pp. 1625 - 1629
• Main Authors: Chugh, Sumeet S, Senashova, Olga, Watts, Allison, Tran, Phuoc T, Zhou, Zhengfeng, Gong, Qiuming, Titus, Jack L, Hayflick, Susan J
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 05.05.2004; Elsevier Science; Elsevier Limited
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Automation; Biological and medical sciences; Bundle-Branch Block - genetics; Bundle-Branch Block - pathology; Cardiac arrhythmia; Cardiology; Cardiology. Vascular system; Cation Transport Proteins - genetics; Death, Sudden, Cardiac - etiology; Death, Sudden, Cardiac - pathology; Defects; Deoxyribonucleic acid; DNA; Electrocardiography; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Ether-A-Go-Go Potassium Channels; Family medical history; Female; Genetic Predisposition to Disease - genetics; Genetic Testing; Heart; Humans; Intensive care medicine; KCNQ Potassium Channels; KCNQ1 Potassium Channel; Long QT Syndrome - genetics; Long QT Syndrome - pathology; Male; Medical examiners; Medical sciences; Minnesota; Mutagenesis; Mutation; Mutation, Missense - genetics; Patients; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Potassium Channels - genetics; Potassium Channels, Voltage-Gated; Minnesota; United States > US; California; ECG; SSCP; SCD; PCR; LQTS; HEK; Cardiovascular disease; Medical screening; Heart disease; Sudden death; Postmortem

We examined the prevalence of defects in arrhythmia-related candidate genes among patients with unexplained sudden cardiac death (SCD). Patients with unexplained sudden death may constitute up to 5% of overall SCD cases. For such patients, systematic postmortem genetic analysis of archived tissue, u...