Methods for the Preparation and Manufacture of Polymeric Nanoparticles

• Published in: Pharmaceutical research Vol. 26; no. 5; pp. 1025 - 1058
• Main Authors: Vauthier, Christine, Bouchemal, Kawthar
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.05.2009; Springer; Springer Nature B.V
• Subjects: administration & dosage; Animals; Biochemistry; Biological and medical sciences; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedical research; Biomedicine; chemistry; Drug Carriers; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Expert Review; Freeze Drying; gels; General pharmacology; Humans; instrumentation; Materials science; Medical Law; Medical sciences; methods; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Nanoparticles - therapeutic use; nanospheres; Nanotechnology; Nanotechnology - instrumentation; Nanotechnology - methods; Pharmaceutical technology. Pharmaceutical industry; pharmacokinetics; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacy; polymerization; Polymers; Polymers - chemistry; Process engineering; Sterilization; therapeutic use; polymerization; precipitation; nanospheres; purification; nanocapsules; scale-up; polyelectrolyte complex; gel; Nanocapsule; Purification; Pharmaceutical technology; Nanoparticle; Polymerization; Polymer; Colloidal gel; Polyelectrolyte; Precipitation; Preparation; Dosage form; Microparticle; Nanosphere

This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules. The first part summarizes the basic principle of each method of nanoparticle preparation. It presents the most recent innovations and progresses obtained over the last decade...