Methods for the Preparation and Manufacture of Polymeric Nanoparticles

• Published in: Pharmaceutical research Vol. 26; no. 5; pp. 1025 - 1058
• Main Authors: Vauthier, Christine, Bouchemal, Kawthar
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.05.2009; Springer; Springer Nature B.V
• Subjects: administration & dosage; Animals; Biochemistry; Biological and medical sciences; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedical research; Biomedicine; chemistry; Drug Carriers; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Expert Review; Freeze Drying; gels; General pharmacology; Humans; instrumentation; Materials science; Medical Law; Medical sciences; methods; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Nanoparticles - therapeutic use; nanospheres; Nanotechnology; Nanotechnology - instrumentation; Nanotechnology - methods; Pharmaceutical technology. Pharmaceutical industry; pharmacokinetics; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacy; polymerization; Polymers; Polymers - chemistry; Process engineering; Sterilization; therapeutic use; polymerization; precipitation; nanospheres; purification; nanocapsules; scale-up; polyelectrolyte complex; gel; Nanocapsule; Purification; Pharmaceutical technology; Nanoparticle; Polymerization; Polymer; Colloidal gel; Polyelectrolyte; Precipitation; Preparation; Dosage form; Microparticle; Nanosphere
• ISSN: 0724-8741; 1573-904X; 1573-904X
• DOI: 10.1007/s11095-008-9800-3

This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules. The first part summarizes the basic principle of each method of nanoparticle preparation. It presents the most recent innovations and progresses obtained over the last decade and which were not included in previous reviews on the subject. Strategies for the obtaining of nanoparticles with controlled in vivo fate are described in the second part of the review. A paragraph summarizing scaling up of nanoparticle production and presenting corresponding pilot set-up is considered in the third part of the review. Treatments of nanoparticles, applied after the synthesis, are described in the next part including purification, sterilization, lyophilization and concentration. Finally, methods to obtain labelled nanoparticles for in vitro and in vivo investigations are described in the last part of this review.