A short peptide exerts neuroprotective effects on cerebral ischemia–reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis

• Published in: Journal of neuroinflammation Vol. 20; no. 1; pp. 53 - 20
• Main Authors: Li, Yilin, Jin, Tao, Liu, Naixin, Wang, Junsong, Qin, Zihan, Yin, Saige, Zhang, Yingxuan, Fu, Zhe, Wu, Yutong, Wang, Yinglei, Liu, Yixiang, Yang, Meifeng, Pang, Ailan, Sun, Jun, Wang, Ying, Yang, Xinwang
• Format: Journal Article
• Language: English
• Published: England BioMed Central 28.02.2023; BMC
• Subjects: Acute toxicity; Amino acid sequence; Animals; Apoptosis; Blood; Blood-brain barrier; Brain research; Carotid arteries; Cerebral blood flow; Cerebral infarction; Cerebrovascular disease; Drug development; Drugs; Hypoxia; I-kappa B Kinase; IKKβ; Inflammation; Ischemia; Ischemic stroke; Kinases; Males; MicroRNAs; miR-6328; miRNA; Molecular modelling; Mortality; Neurological complications; Neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; NF-kappa B; NF-κB; NF-κB protein; Nucleotide sequence; Oxidative stress; Peptide; Peptides; Peptides - pharmacology; Peptides - therapeutic use; Pheochromocytoma cells; Phosphorylation; Physiology; Protein Serine-Threonine Kinases; Rats; Reperfusion; Reperfusion Injury - drug therapy; Reporter gene; Skin; Stroke; Therapeutic targets; Toxicity; Transcription factors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Veins & arteries; Western blotting; Canada; United States > US; China; NF-κB; Neuroprotection; IKKβ; Ischemic stroke; miR-6328; Peptide

Despite considerable efforts, ischemic stroke (IS) remains a challenging clinical problem. Therefore, the discovery of effective therapeutic and targeted drugs based on the underlying molecular mechanism is crucial for effective IS treatment. A cDNA-encoding peptide was cloned from RNA extracted fro...