A short peptide exerts neuroprotective effects on cerebral ischemia–reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis - Li, Yilin; Jin, Tao; Liu, Naixin; Wang, Junsong; Qin, Zihan; Yin, Saige; Zhang, Yingxuan; Fu, Zhe; Wu, Yutong; Wang, Yinglei; Liu, Yixiang; Yang, Meifeng; et al. (Journal of neuroinflammation, 2023)
Keywords: Acute toxicity; Amino acid sequence; Animals; Apoptosis; Blood; Blood-brain barrier; Brain research; Carotid arteries; Cerebral blood flow; Cerebral infarction; Cerebrovascular disease; Drug development; Drugs; Hypoxia; I-kappa B Kinase; IKKβ; Inflammation; Ischemia; Ischemic stroke; Kinases; Males; MicroRNAs; miR-6328; miRNA; Molecular modelling; Mortality; Neurological complications; Neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; NF-kappa B; NF-κB; NF-κB protein; Nucleotide sequence; Oxidative stress; Peptide; Peptides; Peptides - pharmacology; Peptides - therapeutic use; Pheochromocytoma cells; Phosphorylation; Physiology; Protein Serine-Threonine Kinases; Rats; Reperfusion; Reperfusion Injury - drug therapy; Reporter gene; Skin; Stroke; Therapeutic targets; Toxicity; Transcription factors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Veins & arteries; Western blotting; Canada; United States--US; China; NF-κB; Neuroprotection; IKKβ; Ischemic stroke; miR-6328; Peptide