Trending topics of SIRT1 in tumorigenicity

• Published in: Biochimica et biophysica acta. General subjects Vol. 1865; no. 9; p. 129952
• Main Authors: Garcia-Peterson, Liz M., Li, Xiaoling
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2021
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Bifunctional functions; Cancer; Cancer stem cell; carcinogenesis; Cell Proliferation - drug effects; DNA repair; drug resistance; Drug Screening Assays, Antitumor; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; epigenetics; genetic instability; genome; histones; Humans; immunity; inflammation; Metabolism; metastasis; neoplasm progression; neoplasms; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; relapse; SIRT1; Sirtuin 1 - antagonists & inhibitors; Sirtuin 1 - metabolism; Sirtuins; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; Therapeutic response; therapeutics; Sirtuins; Therapeutic response; Bifunctional functions; Cancer stem cell; Metabolism; SIRT1; Cancer

Carcinogenesis is governed by a series of genetic alterations and epigenetic changes that lead to aberrant patterns in neoplastic cells. Sirtuin-1(SIRT1), an NAD+-dependent protein deacetylase, is capable of deacetylating histones and non-histone substrates that regulate various physiological activi...