Patterns of Recombination and MLH1 Foci Density Along Mouse Chromosomes: Modeling Effects of Interference and Obligate Chiasma
Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is mod...
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| Published in | Genetics (Austin) Vol. 176; no. 3; pp. 1453 - 1467 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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United States
Genetics Soc America
01.07.2007
Genetics Society of America Oxford University Press Copyright © 2007 by the Genetics Society of America |
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| Abstract | Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed along the chromosome, and starting from its position, subsequent crossovers are placed with forward and backward stationary renewal processes using a chi-square distribution of intercrossover distances. We used our model as well as the standard chi-square model to simulate the patterns of crossover densities along bivalents or chromatids for those having zero, one, two, or three or more crossovers; indeed, such patterns depend on the number of crossovers. With both models, simulated patterns compare very well to those found experimentally in mice, both for MLH1 foci on bivalents and for crossovers on genetic maps. However, our model provides a better fit to experimental data as compared to the standard chi-square model, particularly regarding the distribution of numbers of crossovers per chromosome. Finally, our model predicts an enhancement of the recombination rate near the extremities, which, however, explains only a part of the pattern observed in mouse. |
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| AbstractList | Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed along the chromosome, and starting from its position, subsequent crossovers are placed with forward and backward stationary renewal processes using a chi-square distribution of intercrossover distances. We used our model as well as the standard chi-square model to simulate the patterns of crossover densities along bivalents or chromatids for those having zero, one, two, or three or more crossovers; indeed, such patterns depend on the number of crossovers. With both models, simulated patterns compare very well to those found experimentally in mice, both for MLH1 foci on bivalents and for crossovers on genetic maps. However, our model provides a better fit to experimental data as compared to the standard chi-square model, particularly regarding the distribution of numbers of crossovers per chromosome. Finally, our model predicts an enhancement of the recombination rate near the extremities, which, however, explains only a part of the pattern observed in mouse. Abstract Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of “obligate chiasma” whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed along the chromosome, and starting from its position, subsequent crossovers are placed with forward and backward stationary renewal processes using a chi-square distribution of intercrossover distances. We used our model as well as the standard chi-square model to simulate the patterns of crossover densities along bivalents or chromatids for those having zero, one, two, or three or more crossovers; indeed, such patterns depend on the number of crossovers. With both models, simulated patterns compare very well to those found experimentally in mice, both for MLH1 foci on bivalents and for crossovers on genetic maps. However, our model provides a better fit to experimental data as compared to the standard chi-square model, particularly regarding the distribution of numbers of crossovers per chromosome. Finally, our model predicts an enhancement of the recombination rate near the extremities, which, however, explains only a part of the pattern observed in mouse. Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed along the chromosome, and starting from its position, subsequent crossovers are placed with forward and backward stationary renewal processes using a chi-square distribution of intercrossover distances. We used our model as well as the standard chi-square model to simulate the patterns of crossover densities along bivalents or chromatids for those having zero, one, two, or three or more crossovers; indeed, such patterns depend on the number of crossovers. With both models, simulated patterns compare very well to those found experimentally in mice, both for MLH1 foci on bivalents and for crossovers on genetic maps. However, our model provides a better fit to experimental data as compared to the standard chi-square model, particularly regarding the distribution of numbers of crossovers per chromosome. Finally, our model predicts an enhancement of the recombination rate near the extremities, which, however, explains only a part of the pattern observed in mouse. [PUBLICATION ABSTRACT] Abstract Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of “obligate chiasma” whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed along the chromosome, and starting from its position, subsequent crossovers are placed with forward and backward stationary renewal processes using a chi-square distribution of intercrossover distances. We used our model as well as the standard chi-square model to simulate the patterns of crossover densities along bivalents or chromatids for those having zero, one, two, or three or more crossovers; indeed, such patterns depend on the number of crossovers. With both models, simulated patterns compare very well to those found experimentally in mice, both for MLH1 foci on bivalents and for crossovers on genetic maps. However, our model provides a better fit to experimental data as compared to the standard chi-square model, particularly regarding the distribution of numbers of crossovers per chromosome. Finally, our model predicts an enhancement of the recombination rate near the extremities, which, however, explains only a part of the pattern observed in mouse. |
| Author | Mezard, C de Vienne, D Martin, O. C Falque, M Mercier, R |
| AuthorAffiliation | UMR de Génétique Végétale, INRA, Université Paris-Sud, CNRS, AgroParisTech, F-91190 Gif-sur-Yvette, France, † Station de Génétique et d'Amélioration des Plantes, Institut Jean Pierre Bourgin, INRA, Route de Saint-Cyr, F-78026 Versailles Cedex, France and ‡ Université Paris-Sud, LPTMS, UMR8626, CNRS, F-91405, Orsay, France |
| AuthorAffiliation_xml | – name: UMR de Génétique Végétale, INRA, Université Paris-Sud, CNRS, AgroParisTech, F-91190 Gif-sur-Yvette, France, † Station de Génétique et d'Amélioration des Plantes, Institut Jean Pierre Bourgin, INRA, Route de Saint-Cyr, F-78026 Versailles Cedex, France and ‡ Université Paris-Sud, LPTMS, UMR8626, CNRS, F-91405, Orsay, France |
| Author_xml | – sequence: 1 fullname: Falque, M – sequence: 2 fullname: Mercier, R – sequence: 3 fullname: Mezard, C – sequence: 4 fullname: de Vienne, D – sequence: 5 fullname: Martin, O. C |
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| CitedBy_id | crossref_primary_10_1371_journal_pbio_3000903 crossref_primary_10_1073_pnas_1406846111 crossref_primary_10_1002_cppb_20074 crossref_primary_10_1105_tpc_109_071514 crossref_primary_10_1371_journal_pgen_1002354 crossref_primary_10_1534_genetics_110_124081 crossref_primary_10_1534_genetics_113_155549 crossref_primary_10_1371_journal_pcbi_1005923 crossref_primary_10_1007_s10577_008_1221_y crossref_primary_10_1371_journal_pgen_1005478 crossref_primary_10_1371_journal_pone_0019255 crossref_primary_10_3389_fcell_2021_681123 crossref_primary_10_1134_S1022795411110093 crossref_primary_10_1371_journal_pgen_1010141 crossref_primary_10_1146_annurev_genet_040119_093957 crossref_primary_10_1186_1755_8166_4_10 |
| Cites_doi | 10.1093/genetics/139.2.1031 10.1023/A:1016575925934 10.1242/jcs.02583 10.1016/j.tig.2006.12.007 10.1242/jcs.115.8.1611 10.1007/BF00389540 10.1016/j.cell.2006.05.044 10.1111/j.1469-1809.1985.tb01694.x 10.1086/344714 10.1093/genetics/142.4.1369 10.1093/genetics/126.4.1127 10.1101/gr.8.2.81 10.1046/j.1469-1809.2001.6510079.x 10.1016/j.cub.2005.02.056 10.1073/pnas.75.12.6332 10.1093/genetics/160.4.1631 10.1073/pnas.0600418103 10.1086/376610 10.1101/gad.1165904 10.1111/j.1469-1809.1976.tb00175.x 10.1073/pnas.95.1.247 10.1534/genetics.104.027961 10.1007/s00122-005-1998-4 10.1093/genetics/133.3.681 10.1086/302923 10.1016/j.cell.2006.07.010 10.1007/BF02982376 10.1534/genetics.104.036384 10.1146/annurev.genet.33.1.603 10.1534/genetics.104.040055 10.1371/journal.pbio.0030396 10.1101/gad.317504 10.1534/genetics.104.027789 10.1159/000082400 10.1093/genetics/139.2.1057 10.1073/pnas.0402724101 10.1016/S0092-8674(04)00297-1 10.1007/BF00352262 10.1093/genetics/160.3.1123 10.1042/BST0340531 10.1534/genetics.104.032912 |
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| References | 15802520 - Genetics. 2005 Jun;170(2):807-12 14752007 - Genes Dev. 2004 Jan 15;18(2):117-25 16592601 - Proc Natl Acad Sci U S A. 1978 Dec;75(12):6332-6 8454209 - Genetics. 1993 Mar;133(3):681-91 9419361 - Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):247-52 15736976 - PLoS Biol. 2005 Mar;3(3):e63 15854901 - Curr Biol. 2005 Apr 26;15(8):692-701 8565707 - Chromosoma. 1995 Dec;104(4):308-14 9477334 - Genome Res. 1998 Feb;8(2):81-2 16856852 - Biochem Soc Trans. 2006 Aug;34(Pt 4):531-4 11950880 - J Cell Sci. 2002 Apr 15;115(Pt 8):1611-22 12199146 - Chromosome Res. 2002;10(4):329-45 16873056 - Cell. 2006 Jul 28;126(2):246-8 6545727 - Symp Soc Exp Biol. 1984;38:293-320 8846913 - Genetics. 1996 Apr;142(4):1369-77 7713408 - Genetics. 1995 Feb;139(2):1057-65 15489296 - Genes Dev. 2004 Oct 15;18(20):2557-70 11901128 - Genetics. 2002 Mar;160(3):1123-31 10690419 - Annu Rev Genet. 1999;33:603-754 12772089 - Am J Hum Genet. 2003 Jul;73(1):188-97 15753577 - Cytogenet Genome Res. 2005;109(1-3):198-204 12432495 - Am J Hum Genet. 2002 Dec;71(6):1353-68 15066278 - Cell. 2004 Apr 2;117(1):9-15 8075499 - Mamm Genome. 1994 May;5(5):253-74 15454526 - Genetics. 2004 Sep;168(1):49-63 16176934 - J Cell Sci. 2005 Oct 15;118(Pt 20):4621-32 15611158 - Genetics. 2004 Dec;168(4):1805-16 15841356 - Theor Appl Genet. 2005 Jun;111(1):100-9 2127577 - Genetics. 1990 Dec;126(4):1127-38 15781706 - Genetics. 2005 Jun;170(2):841-57 7713406 - Genetics. 1995 Feb;139(2):1031-44 16766662 - Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9607-12 17604455 - PLoS Genet. 2007 Jun;3(6):e106 4073834 - Ann Hum Genet. 1985 Jul;49(Pt 3):203-14 15454525 - Genetics. 2004 Sep;168(1):35-48 15299144 - Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12592-7 3163889 - Am J Hum Genet. 1988 Jul;43(1):38-45 10801387 - Am J Hum Genet. 2000 Jun;66(6):1911-26 1015810 - Ann Hum Genet. 1976 Nov;40(2):147-63 11973316 - Genetics. 2002 Apr;160(4):1631-9 11415524 - Ann Hum Genet. 2001 Jan;65(Pt 1):79-93 16873061 - Cell. 2006 Jul 28;126(2):285-95 17208327 - Trends Genet. 2007 Feb;23(2):91-9 (2022110301581498500_BIB34) 2005; 15 (2022110301581498500_BIB44) 1995; 139 (2022110301581498500_BIB30) 2005; 3 (2022110301581498500_BIB9) 1998; 95 (2022110301581498500_BIB14) 2002; 71 (2022110301581498500_BIB12) 2005; 111 (2022110301581498500_BIB10) 2002; 160 (2022110301581498500_BIB46) 2007 (2022110301581498500_BIB6) 1938; 36 (2022110301581498500_BIB29) 1995; 104 (2022110301581498500_BIB36) 2007; 23 (2022110301581498500_BIB17) 2004; 18 (2022110301581498500_BIB3) 2004; 117 (2022110301581498500_BIB39) 2005; 170 (2022110301581498500_BIB45) 1999; 33 (2022110301581498500_BIB2) 2004; 168 (2022110301581498500_BIB26) 2005; 170 (2022110301581498500_BIB32) 2006; 126 (2022110301581498500_BIB20) 1984; 38 (2022110301581498500_BIB1) 2005; 109 (2022110301581498500_BIB33) 1995; 139 (2022110301581498500_BIB15) 1988; 43 (2022110301581498500_BIB42) 1976; 40 (2022110301581498500_BIB41) 2004; 168 (2022110301581498500_BIB38) 1994; 5 (2022110301581498500_BIB5) 2002; 160 (2022110301581498500_BIB13) 1993; 133 (2022110301581498500_BIB8) 1998; 8 (2022110301581498500_BIB23) 1990; 126 (2022110301581498500_BIB40) 2002; 10 (2022110301581498500_BIB21) 2006; 126 (2022110301581498500_BIB7) 2005; 118 (2022110301581498500_BIB18) 2004; 18 (2022110301581498500_BIB47) 2004; 168 (2022110301581498500_BIB27) 1997; 7 (2022110301581498500_BIB28) 1985; 49 (2022110301581498500_BIB24) 2004; 101 (2022110301581498500_BIB16) 1919; 8 (2022110301581498500_BIB4) 2000; 66 (2022110301581498500_BIB43) 1996; 142 (2022110301581498500_BIB37) 2002; 115 (2022110301581498500_BIB31) 2001; 65 (2022110301581498500_BIB22) 1978; 75 (2022110301581498500_BIB25) 1944; 12 (2022110301581498500_BIB35) 2006; 34 (2022110301581498500_BIB19) 2003; 73 (2022110301581498500_BIB11) 2006; 103 |
| References_xml | – volume: 139 start-page: 1031 year: 1995 ident: 2022110301581498500_BIB33 publication-title: Genetics doi: 10.1093/genetics/139.2.1031 – volume: 10 start-page: 329 year: 2002 ident: 2022110301581498500_BIB40 publication-title: Chromosome Res. doi: 10.1023/A:1016575925934 – volume: 7 start-page: 299 year: 1997 ident: 2022110301581498500_BIB27 publication-title: Ann. Appl. Probab. – volume: 118 start-page: 4621 year: 2005 ident: 2022110301581498500_BIB7 publication-title: J. Cell Sci. doi: 10.1242/jcs.02583 – volume: 23 start-page: 91 year: 2007 ident: 2022110301581498500_BIB36 publication-title: Trends Genet. doi: 10.1016/j.tig.2006.12.007 – volume: 115 start-page: 1611 year: 2002 ident: 2022110301581498500_BIB37 publication-title: J. Cell Sci. doi: 10.1242/jcs.115.8.1611 – volume: 5 start-page: 253 year: 1994 ident: 2022110301581498500_BIB38 publication-title: Mamm. Genome doi: 10.1007/BF00389540 – year: 2007 ident: 2022110301581498500_BIB46 publication-title: PLoS Genet. – volume: 12 start-page: 172 year: 1944 ident: 2022110301581498500_BIB25 publication-title: Ann. Eugen. – volume: 126 start-page: 285 year: 2006 ident: 2022110301581498500_BIB32 publication-title: Cell doi: 10.1016/j.cell.2006.05.044 – volume: 49 start-page: 203 year: 1985 ident: 2022110301581498500_BIB28 publication-title: Ann. Hum. Genet. doi: 10.1111/j.1469-1809.1985.tb01694.x – volume: 71 start-page: 1353 year: 2002 ident: 2022110301581498500_BIB14 publication-title: Am. J. Hum. Genet. doi: 10.1086/344714 – volume: 142 start-page: 1369 year: 1996 ident: 2022110301581498500_BIB43 publication-title: Genetics doi: 10.1093/genetics/142.4.1369 – volume: 126 start-page: 1127 year: 1990 ident: 2022110301581498500_BIB23 publication-title: Genetics doi: 10.1093/genetics/126.4.1127 – volume: 8 start-page: 81 year: 1998 ident: 2022110301581498500_BIB8 publication-title: Genome Res. doi: 10.1101/gr.8.2.81 – volume: 65 start-page: 79 year: 2001 ident: 2022110301581498500_BIB31 publication-title: Ann. Hum. Genet. doi: 10.1046/j.1469-1809.2001.6510079.x – volume: 15 start-page: 692 year: 2005 ident: 2022110301581498500_BIB34 publication-title: Curr. Biol. doi: 10.1016/j.cub.2005.02.056 – volume: 75 start-page: 6332 year: 1978 ident: 2022110301581498500_BIB22 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.75.12.6332 – volume: 160 start-page: 1631 year: 2002 ident: 2022110301581498500_BIB10 publication-title: Genetics doi: 10.1093/genetics/160.4.1631 – volume: 103 start-page: 9607 year: 2006 ident: 2022110301581498500_BIB11 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0600418103 – volume: 73 start-page: 188 year: 2003 ident: 2022110301581498500_BIB19 publication-title: Am. J. Hum. Genet. doi: 10.1086/376610 – volume: 18 start-page: 117 year: 2004 ident: 2022110301581498500_BIB18 publication-title: Genes Dev. doi: 10.1101/gad.1165904 – volume: 40 start-page: 147 year: 1976 ident: 2022110301581498500_BIB42 publication-title: Ann. Hum. Genet. doi: 10.1111/j.1469-1809.1976.tb00175.x – volume: 95 start-page: 247 year: 1998 ident: 2022110301581498500_BIB9 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.1.247 – volume: 38 start-page: 293 year: 1984 ident: 2022110301581498500_BIB20 publication-title: Symp. Soc. Exp. Biol. – volume: 168 start-page: 49 year: 2004 ident: 2022110301581498500_BIB47 publication-title: Genetics doi: 10.1534/genetics.104.027961 – volume: 111 start-page: 100 year: 2005 ident: 2022110301581498500_BIB12 publication-title: Theor. Appl. Genet. doi: 10.1007/s00122-005-1998-4 – volume: 133 start-page: 681 year: 1993 ident: 2022110301581498500_BIB13 publication-title: Genetics doi: 10.1093/genetics/133.3.681 – volume: 66 start-page: 1911 year: 2000 ident: 2022110301581498500_BIB4 publication-title: Am. J. Hum. Genet. doi: 10.1086/302923 – volume: 8 start-page: 299 year: 1919 ident: 2022110301581498500_BIB16 publication-title: J. Genet. – volume: 126 start-page: 246 year: 2006 ident: 2022110301581498500_BIB21 publication-title: Cell doi: 10.1016/j.cell.2006.07.010 – volume: 36 start-page: 103 year: 1938 ident: 2022110301581498500_BIB6 publication-title: J. Genet. doi: 10.1007/BF02982376 – volume: 170 start-page: 841 year: 2005 ident: 2022110301581498500_BIB39 publication-title: Genetics doi: 10.1534/genetics.104.036384 – volume: 33 start-page: 603 year: 1999 ident: 2022110301581498500_BIB45 publication-title: Annu. Rev. Genet. doi: 10.1146/annurev.genet.33.1.603 – volume: 170 start-page: 807 year: 2005 ident: 2022110301581498500_BIB26 publication-title: Genetics doi: 10.1534/genetics.104.040055 – volume: 3 start-page: 396 year: 2005 ident: 2022110301581498500_BIB30 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0030396 – volume: 18 start-page: 2557 year: 2004 ident: 2022110301581498500_BIB17 publication-title: Genes Dev. doi: 10.1101/gad.317504 – volume: 168 start-page: 35 year: 2004 ident: 2022110301581498500_BIB41 publication-title: Genetics doi: 10.1534/genetics.104.027789 – volume: 109 start-page: 198 year: 2005 ident: 2022110301581498500_BIB1 publication-title: Cytogenet. Genome Res. doi: 10.1159/000082400 – volume: 139 start-page: 1057 year: 1995 ident: 2022110301581498500_BIB44 publication-title: Genetics doi: 10.1093/genetics/139.2.1057 – volume: 101 start-page: 12592 year: 2004 ident: 2022110301581498500_BIB24 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0402724101 – volume: 117 start-page: 9 year: 2004 ident: 2022110301581498500_BIB3 publication-title: Cell doi: 10.1016/S0092-8674(04)00297-1 – volume: 104 start-page: 308 year: 1995 ident: 2022110301581498500_BIB29 publication-title: Chromosoma doi: 10.1007/BF00352262 – volume: 160 start-page: 1123 year: 2002 ident: 2022110301581498500_BIB5 publication-title: Genetics doi: 10.1093/genetics/160.3.1123 – volume: 43 start-page: 38 year: 1988 ident: 2022110301581498500_BIB15 publication-title: Am. J. Hum. Genet. – volume: 34 start-page: 531 year: 2006 ident: 2022110301581498500_BIB35 publication-title: Biochem. Soc. Trans. doi: 10.1042/BST0340531 – volume: 168 start-page: 1805 year: 2004 ident: 2022110301581498500_BIB2 publication-title: Genetics doi: 10.1534/genetics.104.032912 |
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| Snippet | Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature... Abstract Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological... Abstract Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological... |
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| SubjectTerms | Adaptor Proteins, Signal Transducing Animals Chi-Square Distribution Chromatids Chromosomes, Mammalian Females Genetic recombination Genetics Investigations Kinetics Life Sciences Mice Models, Genetic MutL Protein Homolog 1 Nuclear Proteins Recombination, Genetic |
| Title | Patterns of Recombination and MLH1 Foci Density Along Mouse Chromosomes: Modeling Effects of Interference and Obligate Chiasma |
| URI | http://www.genetics.org/cgi/content/abstract/176/3/1453 https://www.ncbi.nlm.nih.gov/pubmed/17483430 https://www.proquest.com/docview/214139533/abstract/ https://search.proquest.com/docview/70723363 https://hal.science/hal-03818405 https://pubmed.ncbi.nlm.nih.gov/PMC1931555 |
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