An Easy and Reliable Strategy for Making Type I Interferon Signature Analysis Comparable among Research Centers

• Published in: Diagnostics (Basel) Vol. 9; no. 3; p. 113
• Main Authors: Pin, Alessia, Monasta, Lorenzo, Taddio, Andrea, Piscianz, Elisa, Tommasini, Alberto, Tesser, Alessandra
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.09.2019; MDPI
• Subjects: Bioinformatics; biostatistics; Bowel disease; Clinical medicine; Cytokines; data sharing; Datasets; Gene expression; inter-laboratory variability; interferon signature score; interferonopathies; Laboratories; Lupus; Patients; Principal components analysis; Real time; Research centers; Sample size; Software; systemic lupus erythematosus; Values; United States > US; Switzerland; biostatistics; interferon signature score; interferonopathies; systemic lupus erythematosus; inter-laboratory variability; data sharing

Interferon-stimulated genes (ISGs) are a set of genes whose transcription is induced by interferon (IFN). The measure of the expression of ISGs enables calculating an IFN score, which gives an indirect estimate of the exposition of cells to IFN-mediated inflammation. The measure of the IFN score is...