Optimization of the ultrafiltration-assisted extraction of Chinese yam polysaccharide using response surface methodology and its biological activity

Ultrafiltration is a separation process for purifying and concentrating macromolecular solutions. Using Baiyu yam (Dioscorea opposita Thunb) as the raw material, single-factor experiments, Box–Behnken design (BBD) and response surface methodology (RSM) were employed to investigate the effects of the...

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Published in	International Journal of Biological Macromolecules Vol. 121; pp. 1186 - 1193
Main Authors	Xue, Heng-Yue, Li, Jing-Ru, Liu, Yan-Geng, Gao, Qi, Wang, Xiao-Wen, Zhang, Jun-Wei, Tanokura, Masaru, Xue, You-Lin
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 01.01.2019 Elsevier BV
Subjects	2,2-diphenyl-1-picrylhydrazyl absorption anion exchange Antineoplastic Agents Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology antioxidant activity cell growth Cell Line, Tumor Cell Proliferation Cell Proliferation - drug effects Chinese yam polysaccharide Dioscorea Dioscorea - chemistry Dioscorea oppositifolia Dioscorea polystachya experimental design Fourier transform infrared spectroscopy Free Radicals Free Radicals - chemistry galactose glucose Humans Hydrogen-Ion Concentration hydroxyl radicals mannose microstructure Monosaccharides Monosaccharides - analysis Polysaccharides Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology powders Pressure raw materials regression analysis response surface methodology Structural characterization and activities temperature Ultrafiltration Ultrafiltration - methods Ultrafiltration-assisted extraction yams Chinese yam polysaccharide Structural characterization and activities Ultrafiltration-assisted extraction
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Abstract	Ultrafiltration is a separation process for purifying and concentrating macromolecular solutions. Using Baiyu yam (Dioscorea opposita Thunb) as the raw material, single-factor experiments, Box–Behnken design (BBD) and response surface methodology (RSM) were employed to investigate the effects of the ultrafiltration pH, temperature and pressure on the extraction rate of Chinese yam polysaccharide (CYP). The constructed regression model is highly significant, and the optimal ultrafiltration-assisted extraction conditions were determined to be the following: pH 6.5, 20 °C and 0.03 MPa. Under these optimal conditions, a CYP extraction rate of 88.7% was achieved. After purification with anion exchange (DE-52) and size-exclusion (Sephadex G-100) columns, the monosaccharide composition of CYP was determined to be 50.8% glucose, 24.2% mannose and 11.8% galactose. Fourier transform infrared (FT-IR) spectroscopy characterization of CYP confirmed the characteristic absorption peaks of the polysaccharides. The microstructure of CYP exhibited characteristics typical of amorphous powders. CYP also exhibited antioxidant activities, including the scavenging of DPPH radicals, hydroxyl radicals and superoxide anion radicals. Moreover, CYP exhibited a relatively strong inhibitory effect on BGC-823 cell growth.
AbstractList	Ultrafiltration is a separation process for purifying and concentrating macromolecular solutions. Using Baiyu yam (Dioscorea opposita Thunb) as the raw material, single-factor experiments, Box-Behnken design (BBD) and response surface methodology (RSM) were employed to investigate the effects of the ultrafiltration pH, temperature and pressure on the extraction rate of Chinese yam polysaccharide (CYP). The constructed regression model is highly significant, and the optimal ultrafiltration-assisted extraction conditions were determined to be the following: pH 6.5, 20 °C and 0.03 MPa. Under these optimal conditions, a CYP extraction rate of 88.7% was achieved. After purification with anion exchange (DE-52) and size-exclusion (Sephadex G-100) columns, the monosaccharide composition of CYP was determined to be 50.8% glucose, 24.2% mannose and 11.8% galactose. Fourier transform infrared (FT-IR) spectroscopy characterization of CYP confirmed the characteristic absorption peaks of the polysaccharides. The microstructure of CYP exhibited characteristics typical of amorphous powders. CYP also exhibited antioxidant activities, including the scavenging of DPPH radicals, hydroxyl radicals and superoxide anion radicals. Moreover, CYP exhibited a relatively strong inhibitory effect on BGC-823 cell growth. Ultrafiltration is a separation process for purifying and concentrating macromolecular solutions. Using Baiyu yam (Dioscorea opposita Thunb) as the raw material, single-factor experiments, Box-Behnken design (BBD) and response surface methodology (RSM) were employed to investigate the effects of the ultrafiltration pH, temperature and pressure on the extraction rate of Chinese yam polysaccharide (CYP). The constructed regression model is highly significant, and the optimal ultrafiltration-assisted extraction conditions were determined to be the following: pH 6.5, 20 °C and 0.03 MPa. Under these optimal conditions, a CYP extraction rate of 88.7% was achieved. After purification with anion exchange (DE-52) and size-exclusion (Sephadex G-100) columns, the monosaccharide composition of CYP was determined to be 50.8% glucose, 24.2% mannose and 11.8% galactose. Fourier transform infrared (FT-IR) spectroscopy characterization of CYP confirmed the characteristic absorption peaks of the polysaccharides. The microstructure of CYP exhibited characteristics typical of amorphous powders. CYP also exhibited antioxidant activities, including the scavenging of DPPH radicals, hydroxyl radicals and superoxide anion radicals. Moreover, CYP exhibited a relatively strong inhibitory effect on BGC-823 cell growth.Ultrafiltration is a separation process for purifying and concentrating macromolecular solutions. Using Baiyu yam (Dioscorea opposita Thunb) as the raw material, single-factor experiments, Box-Behnken design (BBD) and response surface methodology (RSM) were employed to investigate the effects of the ultrafiltration pH, temperature and pressure on the extraction rate of Chinese yam polysaccharide (CYP). The constructed regression model is highly significant, and the optimal ultrafiltration-assisted extraction conditions were determined to be the following: pH 6.5, 20 °C and 0.03 MPa. Under these optimal conditions, a CYP extraction rate of 88.7% was achieved. After purification with anion exchange (DE-52) and size-exclusion (Sephadex G-100) columns, the monosaccharide composition of CYP was determined to be 50.8% glucose, 24.2% mannose and 11.8% galactose. Fourier transform infrared (FT-IR) spectroscopy characterization of CYP confirmed the characteristic absorption peaks of the polysaccharides. The microstructure of CYP exhibited characteristics typical of amorphous powders. CYP also exhibited antioxidant activities, including the scavenging of DPPH radicals, hydroxyl radicals and superoxide anion radicals. Moreover, CYP exhibited a relatively strong inhibitory effect on BGC-823 cell growth.
Author	Gao, Qi Wang, Xiao-Wen Liu, Yan-Geng Tanokura, Masaru Li, Jing-Ru Zhang, Jun-Wei Xue, You-Lin Xue, Heng-Yue
Author_xml	– sequence: 1 givenname: Heng-Yue surname: Xue fullname: Xue, Heng-Yue organization: College of Light Industry, Liaoning University, Shenyang 110036, PR China – sequence: 2 givenname: Jing-Ru surname: Li fullname: Li, Jing-Ru organization: College of Light Industry, Liaoning University, Shenyang 110036, PR China – sequence: 3 givenname: Yan-Geng surname: Liu fullname: Liu, Yan-Geng organization: College of Light Industry, Liaoning University, Shenyang 110036, PR China – sequence: 4 givenname: Qi surname: Gao fullname: Gao, Qi organization: Liaoning Administrative College, Shenyang 110161, PR China – sequence: 5 givenname: Xiao-Wen surname: Wang fullname: Wang, Xiao-Wen organization: College of Light Industry, Liaoning University, Shenyang 110036, PR China – sequence: 6 givenname: Jun-Wei surname: Zhang fullname: Zhang, Jun-Wei organization: College of Light Industry, Liaoning University, Shenyang 110036, PR China – sequence: 7 givenname: Masaru orcidid: 0000-0001-5072-2480 surname: Tanokura fullname: Tanokura, Masaru organization: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan – sequence: 8 givenname: You-Lin surname: Xue fullname: Xue, You-Lin email: xueyoulin@lnu.edu.cn organization: College of Light Industry, Liaoning University, Shenyang 110036, PR China
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Keywords	Chinese yam polysaccharide Structural characterization and activities Ultrafiltration-assisted extraction
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Snippet	Ultrafiltration is a separation process for purifying and concentrating macromolecular solutions. Using Baiyu yam (Dioscorea opposita Thunb) as the raw...
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SubjectTerms	2,2-diphenyl-1-picrylhydrazyl absorption anion exchange Antineoplastic Agents Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology antioxidant activity cell growth Cell Line, Tumor Cell Proliferation Cell Proliferation - drug effects Chinese yam polysaccharide Dioscorea Dioscorea - chemistry Dioscorea oppositifolia Dioscorea polystachya experimental design Fourier transform infrared spectroscopy Free Radicals Free Radicals - chemistry galactose glucose Humans Hydrogen-Ion Concentration hydroxyl radicals mannose microstructure Monosaccharides Monosaccharides - analysis Polysaccharides Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology powders Pressure raw materials regression analysis response surface methodology Structural characterization and activities temperature Ultrafiltration Ultrafiltration - methods Ultrafiltration-assisted extraction yams
Title	Optimization of the ultrafiltration-assisted extraction of Chinese yam polysaccharide using response surface methodology and its biological activity
URI	https://dx.doi.org/10.1016/j.ijbiomac.2018.10.126 https://cir.nii.ac.jp/crid/1870865117895330176 https://www.ncbi.nlm.nih.gov/pubmed/30342144 https://www.proquest.com/docview/2123715636 https://www.proquest.com/docview/2189530316
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