An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages

• Published in: Biochimica et biophysica acta Vol. 1862; no. 1; pp. 61 - 70
• Main Authors: Boakye, Yaw Duah, Groyer, Laura, Heiss, Elke H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2018
• Subjects: Active Transport, Cell Nucleus - drug effects; Animals; anti-inflammatory activity; Anti-Inflammatory Agents - pharmacology; Autophagy; Autophagy - drug effects; bioavailability; Cell Nucleus - metabolism; cell viability; CHO Cells; confocal microscopy; coumarins; Coumarins - pharmacology; Cricetinae; Cricetulus; fluorometry; gene expression; Geraniin; HEK293 Cells; Humans; intestinal microorganisms; Lipopolysaccharides - toxicity; M1 polarization; Macrophages; Macrophages - metabolism; Mice; mTOR; nitric oxide; Nitric Oxide - metabolism; Phyllanthus; ral GTP-Binding Proteins - metabolism; rapamycin; Reactive Oxygen Species - metabolism; reporter genes; transcription factor NF-kappa B; Transcription Factor RelA - metabolism; Urolithin A; Western blotting; mTOR; Urolithin A; Macrophages; M1 polarization; Autophagy; Geraniin

An extract of Phyllanthus muellerianus and its constituent geraniin have been reported to exert anti-inflammatory activity in vivo. However, orally consumed geraniin, an ellagitannin, shows low bioavailability and undergoes metabolization to urolithins by gut microbiota. This study aimed at comparin...