Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects

• Published in: Archives of toxicology Vol. 82; no. 1; pp. 29 - 36
• Main Authors: Rezende, Vania B., Barbosa, Fernando, Montenegro, Marcelo F., Sandrim, Valeria C., Gerlach, Raquel F., Tanus-Santos, Jose E.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.01.2008; Springer; Springer Nature B.V
• Subjects: Adult; Alleles; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Chemical and industrial products toxicology. Toxic occupational diseases; Deoxyribonucleases, Type II Site-Specific - genetics; Environmental Exposure; Environmental Health; Female; Freeze Drying; Genotype; Haplotypes; Humans; Inorganic Compounds; Lead - blood; Male; Mass Spectrometry; Medical sciences; Metals and various inorganic compounds; Occupational Medicine/Industrial Medicine; Pharmacology/Toxicology; Polymorphism, Single Nucleotide - genetics; Receptors, Calcitriol - genetics; Reverse Transcriptase Polymerase Chain Reaction; Spectrophotometry, Atomic; Toxicology; Vitamin D; Plasma lead; Whole blood lead; Haplotype; Toxicogenetics; Vitamin D receptor; Polymorphism; Human; Genetic variability; Genotype; Heavy metal; Blood plasma; Whole blood; Vitamin D; Lead; Biological receptor

Genetic factors influence whole blood lead (Pb-B) concentrations in lead exposed subjects. This study aimed at examining the combined effects (haplotype analysis) of three polymorphisms ( BsmI , ApaI and FokI ) in vitamin D receptor (VDR) gene on Pb-B and on the concentrations of lead in plasma (Pb-...