Protective genes and pathways in Alzheimer’s disease: moving towards precision interventions

• Published in: Molecular neurodegeneration Vol. 16; no. 1; pp. 29 - 16
• Main Authors: Seto, Mabel, Weiner, Rebecca L., Dumitrescu, Logan, Hohman, Timothy J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.04.2021; BMC
• Subjects: Age of Onset; Alzheimer Disease - genetics; Alzheimer Disease - prevention & control; Alzheimer's disease; Alzheimer’s; Apolipoproteins E - genetics; Cognitive ability; Dementia; Disease Resistance - genetics; Endosomes - physiology; Etiology; Gene Ontology; Genes; Genetic; Genetic factors; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomes; Homeostasis; Humans; Immunity - immunology; Inflammation; Klotho Proteins - genetics; Klotho Proteins - physiology; Lipid Metabolism; Lysosomes - physiology; Mutation; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - physiology; Neurodegeneration; Neurodegenerative diseases; Neuropathology; Older people; Pathology; Polymorphism, Single Nucleotide; Precision Medicine; Protection; Resilience; Review; Synapses - physiology; Genetic; Protection; Alzheimer’s; Resilience

Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that is characterized by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks. The etiology of Alzheimer’s is complex, with numerous environmental and genetic factors contributing to the diseas...