A new method using Raman spectroscopy for in vivo targeted brain cancer tissue biopsy
Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach. Targeting errors and cancer heterogeneity causing inaccurate sampling are important limitations of this blind technique leading to non-diagn...
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| Published in | Scientific reports Vol. 8; no. 1; pp. 1792 - 10 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Nature Publishing Group
29.01.2018
Nature Publishing Group UK |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach. Targeting errors and cancer heterogeneity causing inaccurate sampling are important limitations of this blind technique leading to non-diagnostic or poor quality samples, and the need for repeated biopsies pose elevated patient risk. An optical technology that can analyze the molecular nature of the tissue prior to harvesting could improve cancer targeting and mitigate patient risk. Here we report on the design, development, and validation of an in situ intraoperative, label-free, cancer detection system based on high wavenumber Raman spectroscopy. This optical detection device was engineered into a commercially available biopsy system allowing tumor analysis prior to tissue harvesting without disrupting workflow. Using a dual validation approach we show that high wavenumber Raman spectroscopy can detect human dense cancer with >60% cancer cells in situ during surgery with a sensitivity and specificity of 80% and 90%, respectively. We also demonstrate for the first time the use of this system in a swine brain biopsy model. These studies set the stage for the clinical translation of this optical molecular imaging method for high yield and safe targeted biopsy. |
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| AbstractList | Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach. Targeting errors and cancer heterogeneity causing inaccurate sampling are important limitations of this blind technique leading to non-diagnostic or poor quality samples, and the need for repeated biopsies pose elevated patient risk. An optical technology that can analyze the molecular nature of the tissue prior to harvesting could improve cancer targeting and mitigate patient risk. Here we report on the design, development, and validation of an in situ intraoperative, label-free, cancer detection system based on high wavenumber Raman spectroscopy. This optical detection device was engineered into a commercially available biopsy system allowing tumor analysis prior to tissue harvesting without disrupting workflow. Using a dual validation approach we show that high wavenumber Raman spectroscopy can detect human dense cancer with >60% cancer cells in situ during surgery with a sensitivity and specificity of 80% and 90%, respectively. We also demonstrate for the first time the use of this system in a swine brain biopsy model. These studies set the stage for the clinical translation of this optical molecular imaging method for high yield and safe targeted biopsy. Abstract Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach. Targeting errors and cancer heterogeneity causing inaccurate sampling are important limitations of this blind technique leading to non-diagnostic or poor quality samples, and the need for repeated biopsies pose elevated patient risk. An optical technology that can analyze the molecular nature of the tissue prior to harvesting could improve cancer targeting and mitigate patient risk. Here we report on the design, development, and validation of an in situ intraoperative, label-free, cancer detection system based on high wavenumber Raman spectroscopy. This optical detection device was engineered into a commercially available biopsy system allowing tumor analysis prior to tissue harvesting without disrupting workflow. Using a dual validation approach we show that high wavenumber Raman spectroscopy can detect human dense cancer with >60% cancer cells in situ during surgery with a sensitivity and specificity of 80% and 90%, respectively. We also demonstrate for the first time the use of this system in a swine brain biopsy model. These studies set the stage for the clinical translation of this optical molecular imaging method for high yield and safe targeted biopsy. Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach. Targeting errors and cancer heterogeneity causing inaccurate sampling are important limitations of this blind technique leading to non-diagnostic or poor quality samples, and the need for repeated biopsies pose elevated patient risk. An optical technology that can analyze the molecular nature of the tissue prior to harvesting could improve cancer targeting and mitigate patient risk. Here we report on the design, development, and validation of an in situ intraoperative, label-free, cancer detection system based on high wavenumber Raman spectroscopy. This optical detection device was engineered into a commercially available biopsy system allowing tumor analysis prior to tissue harvesting without disrupting workflow. Using a dual validation approach we show that high wavenumber Raman spectroscopy can detect human dense cancer with >60% cancer cells in situ during surgery with a sensitivity and specificity of 80% and 90%, respectively. We also demonstrate for the first time the use of this system in a swine brain biopsy model. These studies set the stage for the clinical translation of this optical molecular imaging method for high yield and safe targeted biopsy. |
| ArticleNumber | 1792 |
| Author | Jermyn, Michael Picot, Fabien Urmey, Kirk Desroches, Joannie Trudel, Dominique Petrecca, Kevin Wilson, Brian C Marple, Eric Obaid, Sami Pinto, Michael Leblond, Frédéric Soulez, Gilles Tremblay, Marie-Andrée Guiot, Marie-Christine |
| Author_xml | – sequence: 1 givenname: Joannie surname: Desroches fullname: Desroches, Joannie organization: Centre de Recherche du Centre Hospitalier de l'Université de Montréal, 900 rue, Saint-Denis, H2X 0A9, QC, Canada – sequence: 2 givenname: Michael surname: Jermyn fullname: Jermyn, Michael organization: Brain Tumour Research Centre, Montreal Neurological Institute and Hospital, Dept. of Neurology and Neurosurgery, McGill University, 3801 University St., Montreal, QC, H3A 2B4, Canada – sequence: 3 givenname: Michael surname: Pinto fullname: Pinto, Michael organization: Dept. of Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada – sequence: 4 givenname: Fabien surname: Picot fullname: Picot, Fabien organization: Dept. of Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada – sequence: 5 givenname: Marie-Andrée surname: Tremblay fullname: Tremblay, Marie-Andrée organization: Dept. of Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada – sequence: 6 givenname: Sami surname: Obaid fullname: Obaid, Sami organization: Division of Neurosurgery, Hôpital Notre-Dame du CHUM, University of Montreal, Montreal, 1560 Sherbrooke E, Montreal, QC H2L 4M1, Canada – sequence: 7 givenname: Eric surname: Marple fullname: Marple, Eric organization: EMVision LLC, 1471 F Road, Loxahatchee, Florida, 33470, United States – sequence: 8 givenname: Kirk surname: Urmey fullname: Urmey, Kirk organization: EMVision LLC, 1471 F Road, Loxahatchee, Florida, 33470, United States – sequence: 9 givenname: Dominique surname: Trudel fullname: Trudel, Dominique organization: Department of Pathology, Centre Hospitalier Universitaire de Montréal, 1058 Rue Saint-Denis, Montreal, Québec, H2X 3J4, Canada – sequence: 10 givenname: Gilles surname: Soulez fullname: Soulez, Gilles organization: Centre hospitalier de L'Université de Montréal, Hôpital Notre-Dame-Pavillon Lachapelle, Montréal, QC, H2L 4M1, Canada – sequence: 11 givenname: Marie-Christine surname: Guiot fullname: Guiot, Marie-Christine organization: Division of Neuropathology, Department of Pathology, Montreal Neurological Institute and Hospital, McGill University, 3801 University St, Montreal, QC, H3A 2B4, Canada – sequence: 12 givenname: Brian C surname: Wilson fullname: Wilson, Brian C organization: University Health Network/University of Toronto, TMDT 15-314, 101 College St., Toronto, ON, M5G 1L7, Canada – sequence: 13 givenname: Kevin surname: Petrecca fullname: Petrecca, Kevin email: Kevin.petrecca@mcgill.ca organization: Brain Tumour Research Centre, Montreal Neurological Institute and Hospital, Dept. of Neurology and Neurosurgery, McGill University, 3801 University St., Montreal, QC, H3A 2B4, Canada. Kevin.petrecca@mcgill.ca – sequence: 14 givenname: Frédéric surname: Leblond fullname: Leblond, Frédéric email: Frederic.leblond@polymtl.ca, Frederic.leblond@polymtl.ca organization: Centre de Recherche du Centre Hospitalier de l'Université de Montréal, 900 rue, Saint-Denis, H2X 0A9, QC, Canada. Frederic.leblond@polymtl.ca |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29379121$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0959-8049(03)00421-0 10.1016/j.aca.2012.11.007 10.1038/pcan.2009.42 10.1126/scitranslmed.aaa2384 10.1039/C5AN01786F 10.1366/000370205775142548 10.1126/scitranslmed.3005954 10.1366/0003702991947225 10.1039/b705029a 10.1200/JCO.2015.61.6870 10.1002/jrs.1250250105 10.1088/0031-9155/45/2/201 10.1021/ac0505730 10.1016/j.jocn.2014.10.004 10.1016/S0022-5347(05)00957-2 10.1158/0008-5472.CAN-17-0668 10.1021/ac0616512 10.1366/000370207782597003 10.1148/radiology.192.3.8058949 10.1038/srep28771 10.1007/s00701-007-1473-x 10.1007/s00216-015-9021-7 10.1021/cr300147r 10.2214/AJR.11.7284 10.1364/OL.38.000266 10.1002/(SICI)1097-0142(19980501)82:9<1756::AID-CNCR23>3.0.CO;2-2 10.1227/NEU.0000000000001365 10.1007/s00701-012-1290-8 10.1111/j.1464-410X.2007.06868.x 10.7326/0003-4819-155-3-201108020-00003 10.1016/j.clon.2004.12.005 10.1016/j.jtcvs.2014.12.057 10.1016/j.eururo.2013.05.049 10.5114/jcb.2016.59216 10.1016/j.pdpdt.2013.01.008 10.1159/000222661 10.1148/radiol.2323031224 10.1080/05704920701551530 10.1007/s11060-013-1142-2 10.1038/nrclinonc.2009.18 10.1002/jbio.201500252 10.1038/nrurol.2013.322 10.1364/OE.20.026117 10.1364/BOE.6.002380 10.1007/s11060-013-1326-9 10.1007/s00401-016-1545-1 10.1007/s00701-010-0752-0 10.1364/OL.25.001520 10.1001/jama.289.10.1288 10.1366/0003702053641450 |
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| References | 19333226 - Nat Rev Clin Oncol. 2009 Apr;6(4):197-206 27643918 - Neurosurgery. 2016 Oct;79(4):604-12 22997403 - AJR Am J Roentgenol. 2012 Oct;199(4):W520-2 16600713 - J Urol. 2006 May;175(5):1605-12 20680649 - Acta Neurochir (Wien). 2010 Nov;152(11):1915-21 16390587 - Appl Spectrosc. 2005 Dec;59(12):1485-92 23381406 - Opt Lett. 2013 Feb 1;38(3):266-8 17428241 - BJU Int. 2007 Jun;99(6):1340-4 25673764 - Sci Transl Med. 2015 Feb 11;7(274):274ra19 23787356 - Eur Urol. 2013 Dec;64(6):876-92 18028702 - Appl Spectrosc. 2007 Nov;61(11):1225-32 15901323 - Appl Spectrosc. 2005 Apr;59(4):393-400 23187467 - Opt Express. 2012 Nov 19;20(24):26117-26 27157931 - Acta Neuropathol. 2016 Jun;131(6):803-20 23697873 - Chem Rev. 2013 Aug 14;113(8):5766-81 25943888 - Acta Neuropathol. 2015 Jun;129(6):829-48 25648484 - J Thorac Cardiovasc Surg. 2015 May;149(5):1394-401.e1 24418806 - Nat Rev Urol. 2014 Feb;11(2):80-6 15997914 - Clin Oncol (R Coll Radiol). 2005 Jun;17(4):219-27 18066265 - Opt Lett. 2000 Oct 15;25(20):1520-2 27364229 - Sci Rep. 2016 Jul 01;6:28771 22297399 - Acta Neurochir (Wien). 2012 Apr;154(4):585-8; discussion 588 27257413 - J Contemp Brachytherapy. 2016 Apr;8(2):104-9 24390405 - J Neurooncol. 2014 Feb;116(3):477-85 17710265 - Analyst. 2007 Sep;132(9):899-905 9576298 - Cancer. 1998 May 1;82(9):1749-55 26261262 - J Clin Oncol. 2015 Nov 1;33(31):3541-3 23993846 - Photodiagnosis Photodyn Ther. 2013 Sep;10(3):207-19 12888361 - Eur J Cancer. 2003 Aug;39(12):1676-83 19494566 - Stereotact Funct Neurosurg. 2009;87(3):174-81 10701500 - Phys Med Biol. 2000 Feb;45(2):R1-59 26416020 - Anal Bioanal Chem. 2015 Nov;407(27):8311-20 23265730 - Anal Chim Acta. 2013 Jan 14;760:25-33 26856796 - J Biophotonics. 2016 May;9(5):490-8 23677747 - J Neurooncol. 2013 Jul;113(3):495-503 21810706 - Ann Intern Med. 2011 Aug 2;155(3):137-44 25533211 - J Clin Neurosci. 2015 Mar;22(3):437-44 12633191 - JAMA. 2003 Mar 12;289(10 ):1288-96 19786982 - Prostate Cancer Prostatic Dis. 2010 Mar;13(1):71-7 15273332 - Radiology. 2004 Sep;232(3):897-903 18172567 - Acta Neurochir (Wien). 2008 Jan;150(1):23-9 17222020 - Anal Chem. 2007 Jan 15;79(2):557-64 16223266 - Anal Chem. 2005 Oct 15;77(20):6747-52 26203368 - Biomed Opt Express. 2015 Jun 08;6(7):2380-97 8058949 - Radiology. 1994 Sep;192(3):793-5 28659435 - Cancer Res. 2017 Jul 15;77(14 ):3942-3950 24005159 - Sci Transl Med. 2013 Sep 4;5(201):201ra119 T Siegal (20233_CR52) 2015; 22 R Dammers (20233_CR5) 2010; 152 LF Santos (20233_CR35) 2005; 77 IEI Petterson (20233_CR21) 2015; 407 G Campe (20233_CR13) 2012; 154 M Ji (20233_CR27) 2013; 5 R Dammers (20233_CR8) 2008; 150 S Koljenović (20233_CR34) 2007; 79 A Mizuno (20233_CR25) 1994; 25 20233_CR28 VL Chiou (20233_CR1) 2015; 33 C Beleites (20233_CR37) 2013; 760 J Torres-Reveron (20233_CR46) 2013; 113 O Lauche (20233_CR48) 2016; 8 GC Morton (20233_CR47) 2005; 17 BG Muller (20233_CR20) 2016; 9 EB Hanlon (20233_CR30) 2000; 45 20233_CR31 M Jermyn (20233_CR23) 2015; 7 Z Movasaghi (20233_CR32) 2007; 42 K Eichler (20233_CR2) 2006; 175 V Pavlov (20233_CR14) 2016; 79 P Matousek (20233_CR38) 2005; 59 X Li (20233_CR16) 2000; 25 HU Ahmed (20233_CR41) 2009; 6 J Zhao (20233_CR49) 2007; 61 20233_CR19 AV Taira (20233_CR3) 2010; 13 MG Shim (20233_CR36) 1999; 53 S Loeb (20233_CR10) 2013; 64 LE Hoorntje (20233_CR45) 2003; 39 M Jermyn (20233_CR50) 2015; 7 LA Austin (20233_CR33) 2015 DN Louis (20233_CR51) 2016; 131 W Göbel (20233_CR15) 2012; 20 FM Lomoschitz (20233_CR43) 2004; 232 20233_CR22 RS Wiener (20233_CR11) 2011; 155 L Liberman (20233_CR44) 1994; 192 SN Kalkanis (20233_CR26) 2014; 116 D Lorenser (20233_CR17) 2013; 38 WA Hall (20233_CR6) 1998; 82 C Kallaway (20233_CR29) 2013; 10 GK Zoeller (20233_CR7) 2009; 87 JME Walsh (20233_CR42) 2003; 289 JS Jones (20233_CR4) 2007; 99 N Stone (20233_CR39) 2007; 132 K Aldape (20233_CR53) 2015; 129 20233_CR12 FME Wagenlehner (20233_CR9) 2014; 11 J Desroches (20233_CR24) 2015; 6 A Curatolo (20233_CR18) 2012; 199 P Matousek (20233_CR40) 2005; 59 |
| References_xml | – volume: 7 start-page: 1 year: 2015 ident: 20233_CR50 publication-title: Intraoperative brain cancer detection with Raman spectroscopy in humans. contributor: fullname: M Jermyn – volume: 39 start-page: 1676 year: 2003 ident: 20233_CR45 publication-title: Eur. J. Cancer doi: 10.1016/S0959-8049(03)00421-0 contributor: fullname: LE Hoorntje – volume: 760 start-page: 25 year: 2013 ident: 20233_CR37 publication-title: Anal. Chim. Acta doi: 10.1016/j.aca.2012.11.007 contributor: fullname: C Beleites – volume: 13 start-page: 71 year: 2010 ident: 20233_CR3 publication-title: Prostate Cancer Prostatic Dis. doi: 10.1038/pcan.2009.42 contributor: fullname: AV Taira – volume: 7 start-page: 274ra19 year: 2015 ident: 20233_CR23 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaa2384 contributor: fullname: M Jermyn – year: 2015 ident: 20233_CR33 publication-title: The Analyst doi: 10.1039/C5AN01786F contributor: fullname: LA Austin – volume: 59 start-page: 1485 year: 2005 ident: 20233_CR38 publication-title: Appl. Spectrosc. doi: 10.1366/000370205775142548 contributor: fullname: P Matousek – volume: 5 start-page: 201ra119 year: 2013 ident: 20233_CR27 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3005954 contributor: fullname: M Ji – volume: 53 start-page: 619 year: 1999 ident: 20233_CR36 publication-title: Appl. Spectrosc. doi: 10.1366/0003702991947225 contributor: fullname: MG Shim – volume: 132 start-page: 899 year: 2007 ident: 20233_CR39 publication-title: Analyst doi: 10.1039/b705029a contributor: fullname: N Stone – volume: 33 start-page: 3541 year: 2015 ident: 20233_CR1 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2015.61.6870 contributor: fullname: VL Chiou – volume: 25 start-page: 25 year: 1994 ident: 20233_CR25 publication-title: J. Raman Spectrosc. doi: 10.1002/jrs.1250250105 contributor: fullname: A Mizuno – volume: 45 start-page: R1 year: 2000 ident: 20233_CR30 publication-title: Phys. Med. Biol. doi: 10.1088/0031-9155/45/2/201 contributor: fullname: EB Hanlon – volume: 77 start-page: 6747 year: 2005 ident: 20233_CR35 publication-title: Anal. Chem. doi: 10.1021/ac0505730 contributor: fullname: LF Santos – volume: 22 start-page: 437 year: 2015 ident: 20233_CR52 publication-title: J. Clin. Neurosci. doi: 10.1016/j.jocn.2014.10.004 contributor: fullname: T Siegal – volume: 175 start-page: 1605 year: 2006 ident: 20233_CR2 publication-title: J. Urol. doi: 10.1016/S0022-5347(05)00957-2 contributor: fullname: K Eichler – ident: 20233_CR28 doi: 10.1158/0008-5472.CAN-17-0668 – volume: 79 start-page: 557 year: 2007 ident: 20233_CR34 publication-title: Anal. Chem. doi: 10.1021/ac0616512 contributor: fullname: S Koljenović – volume: 61 start-page: 1225 year: 2007 ident: 20233_CR49 publication-title: Appl. Spectrosc. doi: 10.1366/000370207782597003 contributor: fullname: J Zhao – volume: 129 start-page: 829 year: 2015 ident: 20233_CR53 publication-title: Glioblastoma: pathology, molecular mechanisms and markers. Acta Neuropathol. (Berl) contributor: fullname: K Aldape – volume: 192 start-page: 793 year: 1994 ident: 20233_CR44 publication-title: Radiology doi: 10.1148/radiology.192.3.8058949 contributor: fullname: L Liberman – ident: 20233_CR19 doi: 10.1038/srep28771 – volume: 150 start-page: 23 year: 2008 ident: 20233_CR8 publication-title: Acta Neurochir. (Wien) doi: 10.1007/s00701-007-1473-x contributor: fullname: R Dammers – volume: 407 start-page: 8311 year: 2015 ident: 20233_CR21 publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-015-9021-7 contributor: fullname: IEI Petterson – ident: 20233_CR22 – ident: 20233_CR31 doi: 10.1021/cr300147r – volume: 199 start-page: W520 year: 2012 ident: 20233_CR18 publication-title: Am. J. Roentgenol. doi: 10.2214/AJR.11.7284 contributor: fullname: A Curatolo – volume: 38 start-page: 266 year: 2013 ident: 20233_CR17 publication-title: Opt. Lett. doi: 10.1364/OL.38.000266 contributor: fullname: D Lorenser – volume: 82 start-page: 1749 year: 1998 ident: 20233_CR6 publication-title: Cancer doi: 10.1002/(SICI)1097-0142(19980501)82:9<1756::AID-CNCR23>3.0.CO;2-2 contributor: fullname: WA Hall – volume: 79 start-page: 604 year: 2016 ident: 20233_CR14 publication-title: Neurosurgery doi: 10.1227/NEU.0000000000001365 contributor: fullname: V Pavlov – volume: 154 start-page: 585 year: 2012 ident: 20233_CR13 publication-title: Acta Neurochir. (Wien) doi: 10.1007/s00701-012-1290-8 contributor: fullname: G Campe – volume: 99 start-page: 1340 year: 2007 ident: 20233_CR4 publication-title: BJU Int. doi: 10.1111/j.1464-410X.2007.06868.x contributor: fullname: JS Jones – volume: 155 start-page: 137 year: 2011 ident: 20233_CR11 publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-155-3-201108020-00003 contributor: fullname: RS Wiener – volume: 17 start-page: 219 year: 2005 ident: 20233_CR47 publication-title: Clin. Oncol. doi: 10.1016/j.clon.2004.12.005 contributor: fullname: GC Morton – ident: 20233_CR12 doi: 10.1016/j.jtcvs.2014.12.057 – volume: 64 start-page: 876 year: 2013 ident: 20233_CR10 publication-title: Eur. Urol. doi: 10.1016/j.eururo.2013.05.049 contributor: fullname: S Loeb – volume: 8 start-page: 104 year: 2016 ident: 20233_CR48 publication-title: J. Contemp. Brachytherapy doi: 10.5114/jcb.2016.59216 contributor: fullname: O Lauche – volume: 10 start-page: 207 year: 2013 ident: 20233_CR29 publication-title: Photodiagnosis Photodyn. Ther. doi: 10.1016/j.pdpdt.2013.01.008 contributor: fullname: C Kallaway – volume: 87 start-page: 174 year: 2009 ident: 20233_CR7 publication-title: Stereotact. Funct. Neurosurg. doi: 10.1159/000222661 contributor: fullname: GK Zoeller – volume: 232 start-page: 897 year: 2004 ident: 20233_CR43 publication-title: Radiology doi: 10.1148/radiol.2323031224 contributor: fullname: FM Lomoschitz – volume: 42 start-page: 493 year: 2007 ident: 20233_CR32 publication-title: Appl. Spectrosc. Rev. doi: 10.1080/05704920701551530 contributor: fullname: Z Movasaghi – volume: 113 start-page: 495 year: 2013 ident: 20233_CR46 publication-title: J. Neurooncol. doi: 10.1007/s11060-013-1142-2 contributor: fullname: J Torres-Reveron – volume: 6 start-page: 197 year: 2009 ident: 20233_CR41 publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2009.18 contributor: fullname: HU Ahmed – volume: 9 start-page: 490 year: 2016 ident: 20233_CR20 publication-title: J. Biophotonics doi: 10.1002/jbio.201500252 contributor: fullname: BG Muller – volume: 11 start-page: 80 year: 2014 ident: 20233_CR9 publication-title: Nat. Rev. Urol. doi: 10.1038/nrurol.2013.322 contributor: fullname: FME Wagenlehner – volume: 20 start-page: 26117 year: 2012 ident: 20233_CR15 publication-title: Opt. Express doi: 10.1364/OE.20.026117 contributor: fullname: W Göbel – volume: 6 start-page: 2380 year: 2015 ident: 20233_CR24 publication-title: Biomed. Opt. Express doi: 10.1364/BOE.6.002380 contributor: fullname: J Desroches – volume: 116 start-page: 477 year: 2014 ident: 20233_CR26 publication-title: J. Neurooncol. doi: 10.1007/s11060-013-1326-9 contributor: fullname: SN Kalkanis – volume: 131 start-page: 803 year: 2016 ident: 20233_CR51 publication-title: Acta Neuropathol. (Berl.) doi: 10.1007/s00401-016-1545-1 contributor: fullname: DN Louis – volume: 152 start-page: 1915 year: 2010 ident: 20233_CR5 publication-title: Acta Neurochir. (Wien) doi: 10.1007/s00701-010-0752-0 contributor: fullname: R Dammers – volume: 25 start-page: 1520 year: 2000 ident: 20233_CR16 publication-title: Opt. Lett. doi: 10.1364/OL.25.001520 contributor: fullname: X Li – volume: 289 start-page: 1288 year: 2003 ident: 20233_CR42 publication-title: JAMA doi: 10.1001/jama.289.10.1288 contributor: fullname: JME Walsh – volume: 59 start-page: 393 year: 2005 ident: 20233_CR40 publication-title: Appl. Spectrosc. doi: 10.1366/0003702053641450 contributor: fullname: P Matousek |
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| Snippet | Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach.... Abstract Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy... |
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| SubjectTerms | Adult Aged Animals Biopsy Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - pathology Cancer Female Humans Male Middle Aged Neuroimaging Raman spectroscopy Sampling Spectrum analysis Spectrum Analysis, Raman - methods Surgery Swine |
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| Title | A new method using Raman spectroscopy for in vivo targeted brain cancer tissue biopsy |
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