Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling

• Published in: Nature communications Vol. 12; no. 1; pp. 1747 - 14
• Main Authors: Yang, Chen, Tian, Chengzhe, Hoffman, Timothy E, Jacobsen, Nicole K, Spencer, Sabrina L
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 19.03.2021; Nature Publishing Group UK; Nature Portfolio
• Subjects: Activating Transcription Factor 4; Anticancer properties; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2 - metabolism; Damage; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA damage; DNA Damage - drug effects; DNA Replication; Drug resistance; Genetic factors; Humans; Inhibitors; MAP kinase; Melanoma; Melanoma - drug therapy; Melanoma - genetics; Mutagenesis; Mutation; Protein Kinase Inhibitors - pharmacology; Resistance factors; Signal transduction; Signal Transduction - drug effects; Signaling; Subpopulations; Transcriptome; Up-Regulation

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