Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers - Hirvonen, J; Goodwin, R S; Li, C-T; Terry, G E; Zoghbi, S S; Morse, C; Pike, V W; Volkow, N D; Huestis, M A; Innis, R B (Molecular psychiatry, 2012)
Keywords: Abstinence; Adult; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Body mass index; Brain research; Cannabinoid CB1 receptors; Cannabinoids; Cannabis; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Chronic exposure; Down-Regulation - drug effects; Drug abuse; Drug withdrawal; Fluorine Radioisotopes; Functional Neuroimaging - methods; Functional Neuroimaging - psychology; Humans; Male; Marijuana; Marijuana Smoking - metabolism; Medical sciences; Medicine; Medicine & Public Health; Mental health; Neuroimaging; Neurosciences; original-article; Pharmacotherapy; Positron emission tomography; Positron-Emission Tomography - methods; Positron-Emission Tomography - psychology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Pyrrolidinones; Receptor density; Receptor, Cannabinoid, CB1 - metabolism; Smoke; Smoking; Substance Withdrawal Syndrome - metabolism; Time Factors; Tobacco; Tomography; Urine; United States--US; Baltimore Maryland; cannabis; receptor; positron emission tomography; receptor imaging; addiction; CB; Radionuclide study; CB1 cannabinoid receptor; Central nervous system; Cannabidaceae; Encephalon; Cannabis; Chronic; Addiction; Smoker; Dicotyledones; Imaging; Cannabinoid receptor; Angiospermae; Spermatophyta; Drug of abuse; Positron emission tomography; Recreational drug; Biological receptor; Emission tomography