HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65

• Published in: Retrovirology Vol. 19; no. 1; pp. 2 - 14
• Main Authors: Fink, Douglas L, Cai, James, Whelan, Matthew V X, Monit, Christopher, Maluquer de Motes, Carlos, Towers, Greg J, Sumner, Rebecca P
• Format: Journal Article
• Language: English
• Published: England BioMed Central 24.01.2022; BMC
• Subjects: Adaptive immunity; Agonists; Animals; Antiviral agents; Complications; Cytokines; Gene expression; Gene therapy; HIV; HIV-2; HIV-2 - genetics; Human immunodeficiency virus; Immune response; Immunomodulator; Infections; Inflammation; Kinases; Lentivirus; Lipopolysaccharides; Mutagenesis; NF-kappa B - metabolism; NF-κB; NF-κB protein; Nuclear transport; p65; Pathogens; Phenotypes; Proteins; SAM Domain and HD Domain-Containing Protein 1 - metabolism; Signal transduction; Simian Immunodeficiency Virus - genetics; SIV; Transcription activation; Transcription factors; Tumor necrosis factor-TNF; Viral Regulatory and Accessory Proteins - genetics; Viral Regulatory and Accessory Proteins - metabolism; Virus-like particles; Viruses; Vpr protein; Vpx; Immunomodulator; NF-κB; SIV; HIV-2; p65; Vpx

The NF-κB family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of NF-κB transcription factors by viral pathogen-associated molecular patterns, such as viral RNA and DNA, is fundamental to anti-viral innate immune defence...