Variants in the interleukin-1 alpha and beta genes, and the risk for periodontal disease in dogs

Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria. In humans, polymorphisms in the IL1A and IL1B genes are the most well-studied genetic polymorphisms associated with periodontal disease (PD). In contrast to human, ther...

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Published inJournal of genetics Vol. 94; no. 4; pp. 651 - 659
Main Authors ALBUQUERQUE, C., MORINHA, F., MAGALHÃES, J., REQUICHA, J., DIAS, I., GUEDES-PINTO, H., BASTOS, E., VIEGAS, C.
Format Journal Article
LanguageEnglish
Published New Delhi Springer India 01.12.2015
Springer
Springer Nature B.V
Subjects
Alleles
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Case-Control Studies
Cytokines
Dental health
Dogs
Ethylenediaminetetraacetic acid
Evolutionary Biology
Genes
Genetic aspects
Genetic diversity
Genetic polymorphisms
Genetic Predisposition to Disease - genetics
Genetic research
Genetic Variation - genetics
Genetics
Genotype
Interleukin-1alpha - genetics
Interleukin-1beta - genetics
Interleukins
Life Sciences
Medical research
Medicine, Experimental
Microbial Genetics and Genomics
Periodontal Diseases - genetics
Plant Genetics and Genomics
Polymorphism
Research Article
Risk
interleukin-1
dog
genetic variations
periodontal disease
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Abstract Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria. In humans, polymorphisms in the IL1A and IL1B genes are the most well-studied genetic polymorphisms associated with periodontal disease (PD). In contrast to human, there is a lack of knowledge on the genetic basis of canine PD. A case–control study was conducted in which a molecular analysis of dog IL1A and IL1B genes was performed. Of the eight genetic variants identified, seven in IL1A gene and one in IL1B gene, IL1A/1_g.388A >C and IL1A/1_g.521T >A showed statistically significant differences between groups (adjusted OR (95% CI): 0.15 (0.03–0.76), P= 0.022; 5.76 (1.03–32.1), P= 0.046, respectively). It suggests that in the studied population the IL1A/1_g.388C allele is associated with a decreased PD risk, whereas the IL1A/1_g.521A allele can confer an increased risk. Additionally, the IL1A/2_g.515G >T variation resulted in a change of amino acid, i.e. glycine to valine. In silico analysis suggests that this change can alter protein structure and function, predicting it to be deleterious or damaging. This work suggests that IL1 genetic variants may be important in PD susceptibility in canines.
AbstractList Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria. In humans, polymorphisms in the IL1A and IL1B genes are the most well-studied genetic polymorphisms associated with periodontal disease (PD). In contrast to human, there is a lack of knowledge on the genetic basis of canine PD. A case-control study was conducted in which a molecular analysis of dog IL1A and IL1B genes was performed. Of the eight genetic variants identified, seven in IL1A gene and one in IL1B gene, IL1A/1_g.388A >C and IL1A/1_g.521T >A showed statistically significant differences between groups (adjusted OR (95% CI): 0.15 (0.03-0.76), P= 0.022; 5.76 (1.03-32.1), P= 0.046, respectively). It suggests that in the studied population the IL1A/1_g.388C allele is associated with a decreased PD risk, whereas the IL1A/1_g.521A allele can confer an increased risk. Additionally, the IL1A/2_g.515G >T variation resulted in a change of amino acid, i.e. glycine to valine. In silico analysis suggests that this change can alter protein structure and function, predicting it to be deleterious or damaging. This work suggests that IL1 genetic variants may be important in PD susceptibility in canines.
Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria.In humans,polymorphisms in the IL1A and IL1B genes are the most well-studied genetic polymorphisms associated with periodontal disease (PD). In contrast to human, there is a lack of knowledge on the genetic basis of canine PD. A case-control study was conducted in which a molecular analysis of dog IL1A and IL1B genes was performed. Of the eight genetic variants identified, seven in IL1A gene and one in IL1B gene, IL1A/1_g.388A>C and IL1A /1_g.521T>A showed statistically significant differences between groups (adjusted OR (95% CI): 0.15 (0.03-0.76),P=0.022; 5.76 (1.03-32.1),P=0.046, respectively). It suggests that in the studied population the IL1A/1_g.388C allele is associated with a decreased PD risk, whereas the IL1A/1_g.521A allele can confer an increased risk. Additionally, the IL1A/2_g.515G>T variation resulted in a change of amino acid, i.e. glycine to valine. In silico analysis suggests that this change can alter protein structure and function, predicting it to be deleterious or damaging. This work suggests that IL1 genetic variants may be important in PD susceptibility in canines.
Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria. In humans, polymorphisms in the IL1A and IL1B genes are the most well-studied genetic polymorphisms associated with periodontal disease (PD). In contrast to human, there is a lack of knowledge on the genetic basis of canine PD. A case–control study was conducted in which a molecular analysis of dog IL1A and IL1B genes was performed. Of the eight genetic variants identified, seven in IL1A gene and one in IL1B gene, IL1A /1_g.388A >C and IL1A /1_g.521T >A showed statistically significant differences between groups (adjusted OR (95% CI): 0.15 (0.03–0.76), P = 0.022; 5.76 (1.03–32.1), P = 0.046, respectively). It suggests that in the studied population the IL1A /1_g.388C allele is associated with a decreased PD risk, whereas the IL1A /1_g.521A allele can confer an increased risk. Additionally, the IL1A /2_g.515G >T variation resulted in a change of amino acid, i.e. glycine to valine. In silico analysis suggests that this change can alter protein structure and function, predicting it to be deleterious or damaging. This work suggests that IL1 genetic variants may be important in PD susceptibility in canines.
Audience Academic
Author BASTOS, E.
DIAS, I.
ALBUQUERQUE, C.
MORINHA, F.
VIEGAS, C.
MAGALHÃES, J.
REQUICHA, J.
GUEDES-PINTO, H.
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Keywords interleukin-1
dog
genetic variations
periodontal disease
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springer_journals_10_1007_s12041_015_0576_z
fao_agris_US201600135423
PublicationCentury 2000
PublicationDate 2015-12-01
PublicationDateYYYYMMDD 2015-12-01
PublicationDate_xml – month: 12
  year: 2015
  text: 2015-12-01
  day: 01
PublicationDecade 2010
PublicationPlace New Delhi
PublicationPlace_xml – name: New Delhi
– name: India
– name: London
PublicationSubtitle Published by the Indian Academy of Sciences
PublicationTitle Journal of genetics
PublicationTitleAbbrev J Genet
PublicationTitleAlternate J Genet
PublicationYear 2015
Publisher Springer India
Springer
Springer Nature B.V
Publisher_xml – name: Springer India
– name: Springer
– name: Springer Nature B.V
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Snippet Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria. In humans, polymorphisms in...
Elevated levels of interleukin-1 (IL-1) have been shown to amplify the inflammatory response against periodontopathogenic bacteria.In humans,polymorphisms in...
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SubjectTerms Alleles
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Case-Control Studies
Cytokines
Dental health
Dogs
Ethylenediaminetetraacetic acid
Evolutionary Biology
Genes
Genetic aspects
Genetic diversity
Genetic polymorphisms
Genetic Predisposition to Disease - genetics
Genetic research
Genetic Variation - genetics
Genetics
Genotype
Interleukin-1alpha - genetics
Interleukin-1beta - genetics
Interleukins
Life Sciences
Medical research
Medicine, Experimental
Microbial Genetics and Genomics
Periodontal Diseases - genetics
Plant Genetics and Genomics
Polymorphism
Research Article
Risk
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Title Variants in the interleukin-1 alpha and beta genes, and the risk for periodontal disease in dogs
URI https://link.springer.com/article/10.1007/s12041-015-0576-z
https://www.ncbi.nlm.nih.gov/pubmed/26690520
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