Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera

• Published in: Experimental hematology Vol. 32; no. 2; pp. 179 - 187
• Main Authors: Ugo, Valérie, Marzac, Christophe, Teyssandier, Irène, Larbret, Frédéric, Lécluse, Yann, Debili, Najet, Vainchenker, William, Casadevall, Nicole
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2004
• Subjects: Antigens, CD34 - analysis; Cell Differentiation - drug effects; Cell Division; Erythroid Precursor Cells - cytology; Erythropoietin - pharmacology; Humans; Leukocyte Common Antigens - analysis; Leukocyte Common Antigens - physiology; Polycythemia Vera - blood; Polycythemia Vera - etiology; Signal Transduction - physiology

Polycythemia vera (PV) is a myeloproliferative disorder arising in a multipotent hematopoietic stem cell. The pathogenesis of PV remains poorly understood; however, the biologic hallmark of this disease is the presence of erythropoietin (Epo)-independent colony formation (endogenous erythroid colony...