Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and Inflammatory Changes in Rats

Depression causes mental and physical changes which affect quality of life. It is estimated to become the second most prevalent disease, but despite its commonness, the pathophysiology of depression remains unclear and medicine is not sufficiently protective. p-Coumaric acid (p-CA) is a dietary phen...

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Published inExperimental neurobiology Vol. 27; no. 3; pp. 189 - 199
Main Authors Lee, Seok, Kim, Hyun-Bum, Hwang, Eun-Sang, Kim, Eun-Seok, Kim, Sung-Soo, Jeon, Tae-Dong, Song, Min-Cheol, Lee, Ji-Seung, Chung, Min-Chan, Maeng, Sungho, Park, Ji-Ho
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Society for Brain and Neural Science 01.06.2018
한국뇌신경과학회
Subjects
Original
뇌과학
Long-term synaptic depression (LTD)
Depression
Cytokines
p-coumaric acid (p-CA)
Lipopolysaccharide (LPS)
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Abstract Depression causes mental and physical changes which affect quality of life. It is estimated to become the second most prevalent disease, but despite its commonness, the pathophysiology of depression remains unclear and medicine is not sufficiently protective. p-Coumaric acid (p-CA) is a dietary phenolic acid which has been proven to have antifungal, anti-HIV, anti-melanogenic, antioxidant and anti-inflammatory effects. Considering these effects, we investigated whether p-CA can prevent depressive symptoms by reducing inflammatory cytokines in animals injected with lipopolysaccharide (LPS). Changes in despair-related behaviors, inflammatory cytokines, neurotrophic factors and synaptic activity were measured. In these animals, p-CA improved despair-related behavioral symptoms induced by LPS in the forced swim test (FST), tail suspension test (TST) and sucrose splash test (SST). p-CA also prevented the increase of inflammatory cytokines in the hippocampus such as cycloxigenase-2 and tumor necrosis factor-α due to LPS. Similarly, it prevented the reduction of brain-derived neurotrophic factor (BDNF) by LPS. Electrophysiologically, p-CA blocked the reduction of long-term depression in LPS-treated organotypic tissue slices. In conclusion, p-CA prevented LPS-induced depressive symptoms in animals, as determined by behavioral, biochemical and electrophysiological measures. These findings suggest the potential use of p-CA as a preventive and therapeutic medicine for depression.
AbstractList Depression causes mental and physical changes which affect quality of life. It is estimated to become the second most prevalent disease, but despite its commonness, the pathophysiology of depression remains unclear and medicine is not sufficiently protective. p-Coumaric acid (p-CA) is a dietary phenolic acid which has been proven to have antifungal, anti-HIV, anti-melanogenic, antioxidant and anti-inflammatory effects. Considering these effects, we investigated whether p-CA can prevent depressive symptoms by reducing inflammatory cytokines in animals injected with lipopolysaccharide (LPS). Changes in despair-related behaviors, inflammatory cytokines, neurotrophic factors and synaptic activity were measured. In these animals, p-CA improved despair-related behavioral symptoms induced by LPS in the forced swim test (FST), tail suspension test (TST) and sucrose splash test (SST). p-CA also prevented the increase of inflammatory cytokines in the hippocampus such as cycloxigenase-2 and tumor necrosis factor-α due to LPS. Similarly, it prevented the reduction of brain-derived neurotrophic factor (BDNF) by LPS. Electrophysiologically, p-CA blocked the reduction of long-term depression in LPS-treated organotypic tissue slices. In conclusion, p-CA prevented LPS-induced depressive symptoms in animals, as determined by behavioral, biochemical and electrophysiological measures. These findings suggest the potential use of p-CA as a preventive and therapeutic medicine for depression.
Depression causes mental and physical changes which affect quality of life. It is estimated to become the second most prevalent disease, but despite its commonness, the pathophysiology of depression remains unclear and medicine is not sufficiently protective. pCoumaric acid (p-CA) is a dietary phenolic acid which has been proven to have antifungal, anti-HIV, anti-melanogenic, antioxidant and anti-inflammatory effects. Considering these effects, we investigated whether p-CA can prevent depressive symptoms by reducing inflammatory cytokines in animals injected with lipopolysaccharide (LPS). Changes in despair-related behaviors, inflammatory cytokines, neurotrophic factors and synaptic activity were measured. In these animals, p-CA improved despair-related behavioral symptoms induced by LPS in the forced swim test (FST), tail suspension test (TST) and sucrose splash test (SST). p-CA also prevented the increase of inflammatory cytokines in the hippocampus such as cycloxigenase-2 and tumor necrosis factor-α due to LPS. Similarly, it prevented the reduction of brain-derived neurotrophic factor (BDNF) by LPS. Electrophysiologically, p-CA blocked the reduction of long-term depression in LPS-treated organotypic tissue slices. In conclusion, p-CA prevented LPS-induced depressive symptoms in animals, as determined by behavioral, biochemical and electrophysiological measures. These findings suggest the potential use of p-CA as a preventive and therapeutic medicine for depression. KCI Citation Count: 4
Author Lee, Seok
Song, Min-Cheol
Kim, Hyun-Bum
Park, Ji-Ho
Kim, Sung-Soo
Lee, Ji-Seung
Maeng, Sungho
Kim, Eun-Seok
Jeon, Tae-Dong
Chung, Min-Chan
Hwang, Eun-Sang
AuthorAffiliation 2 Department of Gerontology, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Korea
1 Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Korea
3 Department of East-West Medicine, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Korea
4 Research Institute of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea
AuthorAffiliation_xml – name: 1 Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Korea
– name: 3 Department of East-West Medicine, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Korea
– name: 2 Department of Gerontology, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Korea
– name: 4 Research Institute of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea
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  organization: Research Institute of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea
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Issue 3
Keywords Long-term synaptic depression (LTD)
Depression
Cytokines
p-coumaric acid (p-CA)
Lipopolysaccharide (LPS)
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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한국뇌신경과학회
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Title Antidepressant-like Effects of p-Coumaric Acid on LPS-induced Depressive and Inflammatory Changes in Rats
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