Recent advances in matrix metalloproteinases-responsive nanoprobes for cancer diagnosis and therapy

• Published in: Reviews in analytical chemistry Vol. 41; no. 1; pp. 198 - 216
• Main Authors: Wang, Qiuye, Cui, Haijing, Gan, Ning, Ma, Xuehua, Ren, Wenzhi, Wu, Aiguo
• Format: Journal Article
• Language: English
• Published: Berlin De Gruyter 17.09.2022; Walter de Gruyter GmbH
• Subjects: Cancer; Diagnosis; enzyme-responsive; Matrix metalloproteinases; Medical imaging; Substrates; Therapy; Tumors

Matrix metalloproteinases (MMPs), a class of zinc-contained endopeptidases, are closely involved in tumor growth, infiltration, metastasis, and angiogenesis. By virtue of the specifically enzymatic hydrolysis, MMPs have been widely used to turn on imaging and/or therapy function of elaborately desig...