Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS

• Published in: The Journal of neuroscience Vol. 26; no. 39; pp. 10006 - 10019
• Main Authors: Yuan, Aidong, Rao, Mala V, Sasaki, Takahiro, Chen, Yuanxin, Kumar, Asok, Veeranna, Liem, Ronald K H, Eyer, Joel, Peterson, Alan C, Julien, Jean-Pierre, Nixon, Ralph A
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 27.09.2006
• Subjects: Animals; Axons - chemistry; Axons - ultrastructure; Crosses, Genetic; Female; Intermediate Filament Proteins - analysis; Intermediate Filament Proteins - deficiency; Intermediate Filament Proteins - genetics; Intermediate Filament Proteins - physiology; Intermediate Filament Proteins - ultrastructure; Intermediate Filaments - chemistry; Intermediate Filaments - ultrastructure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Immunoelectron; Multiprotein Complexes; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Neurofilament Proteins - analysis; Neurofilament Proteins - deficiency; Neurofilament Proteins - genetics; Neurofilament Proteins - physiology; Neurofilament Proteins - ultrastructure; Protein Interaction Mapping; Protein Transport; Rats; Recombinant Fusion Proteins - analysis; Recombinant Fusion Proteins - physiology; Retinal Ganglion Cells - chemistry; Retinal Ganglion Cells - ultrastructure; Spinal Cord - chemistry; Spinal Cord - ultrastructure; Structure-Activity Relationship; Transfection

Alpha-internexin, a neuronal intermediate filament protein implicated in neurodegenerative disease, coexists with the neurofilament (NF) triplet proteins (NF-L, NF-M, and NF-H) but has an unknown function. The earlier peak expression of alpha-internexin than the triplet during brain development and...