A putative "chemokine switch" that regulates systemic acute inflammation in humans

• Published in: Scientific reports Vol. 11; no. 1; p. 9703
• Main Authors: Azhar, Nabil, Namas, Rami A, Almahmoud, Khalid, Zaaqoq, Akram, Malak, Othman A, Barclay, Derek, Yin, Jinling, El-Dehaibi, Fayten, Abboud, Andrew, Simmons, Richard L, Zamora, Ruben, Billiar, Timothy R, Vodovotz, Yoram
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 06.05.2021; Nature Publishing Group UK; Nature Portfolio
• Subjects: Chemokines; CXCL10 protein; Inflammation; IP-10 protein; Monocyte chemoattractant protein 1; Patients; Trauma

Systemic inflammation is complex and likely drives clinical outcomes in critical illness such as that which ensues following severe injury. We obtained time course data on multiple inflammatory mediators in the blood of blunt trauma patients. Using dynamic network analyses, we inferred a novel contr...