First contact: the role of respiratory cilia in host-pathogen interactions in the airways

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 319; no. 4; pp. L603 - L619
• Main Authors: Kuek, Li Eon, Lee, Robert J.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2020
• Subjects: Bacteria; Bacteria - immunology; Cilia; Cilia - metabolism; Epithelial cells; Epithelial Cells - metabolism; Escalators; Fungi; Fungi - immunology; Host-pathogen interactions; Host-Pathogen Interactions - immunology; Humans; Immunity, Innate - immunology; Immunoregulation; Infections; Innate immunity; Intracellular signalling; Mucociliary Clearance - physiology; Mucus; Mucus - metabolism; Pathogens; Respiratory diseases; Respiratory System - immunology; Respiratory tract diseases; Review; Structure-function relationships; Viruses; Viruses - immunology; influenza; Aspergillus; cystic fibrosis; chronic rhinosinusitis; Pseudomonas aeruginosa; coronavirus; lung epithelium; rhinovirus; Hemophilus influenzae; primary ciliary dyskinesia; Streptococcus pneumoniae

Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction with secreted airway mucus to clear inhaled debris and pathogens from the conducting airways. Respiratory cilia are also one of the first contact points between host and inhaled pathogens. Impaired ciliary f...