Metabolomic serum abnormalities in dogs with hepatopathies

• Published in: Scientific reports Vol. 12; no. 1; p. 5329
• Main Authors: Imbery, Carolin A, Dieterle, Frank, Ottka, Claudia, Weber, Corinna, Schlotterbeck, Götz, Müller, Elisabeth, Lohi, Hannes, Giger, Urs
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 29.03.2022; Nature Publishing Group UK; Nature Portfolio
• Subjects: Amino acids; Animals; Dog Diseases; Dogs; Enzymatic activity; Lipoproteins; Liver diseases; Liver Diseases - veterinary; Magnetic resonance spectroscopy; Metabolism; Metabolites; Metabolome; Metabolomics; NMR; Nuclear magnetic resonance; Older people; Phenylalanine; Principal components analysis; Shunts; Tyrosine; Vascular Malformations

Hepatopathies can cause major metabolic abnormalities in humans and animals. This study examined differences in serum metabolomic parameters and patterns in left-over serum samples from dogs with either congenital portosystemic shunts (cPSS, n = 24) or high serum liver enzyme activities (HLEA, n = 2...