IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children

• Published in: Malaria journal Vol. 20; no. 1; p. 196
• Main Authors: Samayoa-Reyes, Gabriela, Jackson, Conner, Ogolla, Sidney, Sabourin, Katherine, Obajemu, Adeola, Dent, Arlene E, Prokunina-Olsson, Ludmilla, Rochford, Rosemary
• Format: Journal Article
• Language: English
• Published: England BioMed Central 21.04.2021; BMC
• Subjects: Alleles; Birth weight; Children; Cohorts; Dehydrogenases; Enzymes; Genetic diversity; Genetic variance; Genotype & phenotype; Genotypes; Hepatitis; Hepatitis C; Human diseases; IFN-λ4; Immune clearance; Infections; Innate Immunity; Interferon; Laboratories; Liver; Malaria; Plasmodium falciparum; Polymorphism; Population; Pregnancy; Proteins; Questionnaires; Respiratory tract; Respiratory tract diseases; Type III Interferon; Vector-borne diseases; Viruses; Kenya; Africa; Plasmodium falciparum; Malaria; IFN-λ4; Innate Immunity; Type III Interferon

Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the IFNL4 gene. Carriers of the IFNL4-dG allele but not the IFNL4-TT allele are able to produce the IFN-λ4 protein. Patients with hepatitis C virus that do...