Effects of bisphenol A on metabolism and evidences of a mode of action mediated through endocrine disruption

• Published in: Molecular and cellular endocrinology Vol. 475; pp. 74 - 91
• Main Authors: Le Magueresse-Battistoni, Brigitte, Multigner, Luc, Beausoleil, Claire, Rousselle, Christophe
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 05.11.2018; Elsevier
• Subjects: Animals; Benzhydryl Compounds; Benzhydryl Compounds - toxicity; Bisphenol A; BPA; Endocrine disruption; Endocrine Disruptors; Endocrine Disruptors - toxicity; Endocrinology and metabolism; Human health and pathology; Humans; Insulin; Insulin Resistance; Life Sciences; Metabolism; Metabolism - drug effects; Obesity; Obesity - metabolism; Phenols; Phenols - toxicity; Toxicology; Toxicology and food chain; Type 2 diabetes; Type 2 diabetes; GTT; HFD; PND; DM; MSCs; MDI; ERβ or ERbeta; PI3K; NEFA; PPRE; ED; Obesity; ERRγ or ERRgamma; TBT; Endocrine disruption; IR; IS; Insulin; PPARγ; Bisphenol A; BPA; GSIS; IAPP; MoA; ERR; IRS-1; Erα or ERalpha; WAT; WB; NHSII; bw; GPER or GPR30; NHS; TDI; GD; GSH; BMI; eGFR; SOD; GR; TD2M; DES; FABP4; TG; BAT; ROSI; ipITT; NHANES; ipGTT; TO; GLUT4

Based on rodent studies after prenatal and/or perinatal or adult exposure, there is now evidence that BPA may increase metabolic disturbances eventually leading to type-2 diabetes development via an ED MoA. In particular, BPA has been shown to alter insulin synthesis and/or release by pancreatic β-c...