The mercurial nature of neutrophils: still an enigma in ARDS?

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 306; no. 3; pp. L217 - L230
• Main Authors: Williams, Andrew E, Chambers, Rachel C
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.02.2014
• Subjects: Animals; Antimicrobial agents; Chemokines - physiology; Cytotoxicity; Humans; Interleukin-8 - physiology; Leukocytes; Lung - physiopathology; Lungs; Neutrophil Infiltration; Neutrophils - pathology; Neutrophils - physiology; Pathogenesis; Peptide Hydrolases - metabolism; Physiology; Respiratory distress syndrome; Respiratory Distress Syndrome, Adult - pathology; Respiratory Distress Syndrome, Adult - physiopathology; Review; chemokine; lung injury; inflammation; neutrophil; ARDS

The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting from direct and indirect insults to the lung. It is characterized by disruption of the endothelial-epithelial barrier, alveolar damage, pulmonary edema, and respiratory failure. A key feature of ARDS is the...