Mechanism of miR-34a in the metabolism of extracellular matrix in fibroblasts of stress urinary incontinence via Nampt-mediated autophagy

• Published in: Cell stress & chaperones Vol. 27; no. 4; pp. 369 - 381
• Main Authors: Zhou, Ying, Li, Hongjuan, Wang, Lu
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Science + Business Media 01.07.2022; Springer Netherlands; Springer Nature B.V
• Subjects: Autophagy; Autophagy - genetics; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell Biology; Cell culture; Extracellular matrix; Extracellular Matrix - metabolism; Female; Females; Fibroblasts; Fibroblasts - metabolism; Gelatinase A; Gelatinase B; Humans; Hygiene; IL-1β; Immunology; Interleukin 1; Matrix metalloproteinases; Metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Neurosciences; Nicotinamide; Nicotinamide Phosphoribosyltransferase - genetics; Nicotinamide Phosphoribosyltransferase - metabolism; Original; ORIGINAL ARTICLE; Reporter gene; Ribonucleic acid; RNA; Tissue inhibitor of metalloproteinase 1; Urinary incontinence; Urinary Incontinence, Stress - genetics; Urinary Incontinence, Stress - metabolism; Vagina; Stress urinary incontinence; Extracellular matrix metabolism; miR-34a; Autophagy; Fibroblast; Nampt

Stress urinary incontinence (SUI) is a troublesome hygienic problem that afflicts the female population and is associated with extracellular matrix (ECM). Herein, we investigated the effects of microRNA (miR)-34a on ECM metabolism in fibroblasts of SUI via mediating nicotinamide phosphoribosyl trans...