Site-specific action of l -3,4-dihydroxyphenylalanine in the striatum but not globus pallidus and substantia nigra pars reticulata evokes dyskinetic movements in chronic l -3,4-dihydroxyphenylalanine-treated 6-hydroxydopamine-lesioned rats

• Published in: Neuroscience Vol. 166; no. 2; pp. 355 - 358
• Main Authors: Buck, K, Voehringer, P, Ferger, B
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 17.03.2010; Elsevier
• Subjects: Animals; Basal ganglia; Biological and medical sciences; Corpus Striatum - drug effects; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; dyskinesia; Dyskinesia, Drug-Induced; Fundamental and applied biological sciences. Psychology; GABA; Globus Pallidus - drug effects; glutamate; in vivo microdialysis; l-dihydroxyphenylalanine; Levodopa - pharmacology; Male; Medical sciences; Microdialysis; Neurology; Oxidopamine; Parkinson's disease; Rats; Rats, Wistar; Substantia Nigra - drug effects; Vertebrates: nervous system and sense organs; Parkinson's disease; substantia nigra pars reticulata; l-dihydroxyphenylalanine; 6-OHDA; GP; l-3,4-dihydroxyphenylalanine; STN; dyskinesia; artificial cerebrospinal fluid; 6-hydroxydopamine; PD; SNr; subthalamic nucleus; GABA; aCSF; l-DOPA; in vivo microdialysis; DA; dopamine; globus pallidus; glutamate; Rat; Central nervous system; L-dihydroxyphenylalanine; Parkinson disease; Oxidopamine; Pallidum; Site of action; Encephalon; Degenerative disease; Nervous system diseases; Rodentia; Basal ganglion; Corpus striatum; Glutamate; Cerebral disorder; Vertebrata; Chronic; Mammalia; Locus niger; Microdialysis; Animal; Central nervous system disease; Excitatory aminoacid; Neurotransmitter; Lesion; Dopa; Extrapyramidal syndrome

Abstract Dyskinesia eventually develops in the majority of Parkinson's disease patients treated with l -3,4-dihydroxyphenylalanine ( l -DOPA). We have investigated the effect of an acute and local administration of l -DOPA, GABA and glutamate to provoke dyskinetic movements in three basal gangl...