Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation

• Published in: Nature communications Vol. 13; no. 1; p. 6407
• Main Authors: Ortiz-Zapater, Elena, Bagley, Dustin C, Hernandez, Virginia Llopis, Roberts, Luke B, Maguire, Thomas J A, Voss, Felizia, Mertins, Philipp, Kirchner, Marieluise, Peset-Martin, Isabel, Woszczek, Grzegorz, Rosenblatt, Jody, Gotthardt, Michael, Santis, George, Parsons, Maddy
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 27.10.2022; Nature Publishing Group UK; Nature Portfolio
• Subjects: Adenovirus; Adenoviruses; Adhesion; Animals; Asthma; Cell adhesion; Cell proliferation; Coxsackievirus; Coxsackieviruses; Cytokines; Cytokines - metabolism; Depletion; Disease Models, Animal; Dust; Epithelial cells; Epithelium; House dust; Humans; Immune system; Inflammation; Inflammation - metabolism; Leukocyte migration; Leukocytes; Leukocytes (neutrophilic); Lung - metabolism; Lung diseases; Mice; Mites; Muscles; Neutrophils; Pneumonia - metabolism; Pyroglyphidae; Receptors; Receptors, Virus - metabolism; Respiratory Mucosa - metabolism; Respiratory tract; Respiratory tract diseases; Smooth muscle; Viruses

Airway inflammation and remodelling are important pathophysiologic features in asthma and other respiratory conditions. An intact epithelial cell layer is crucial to maintain lung homoeostasis, and this depends on intercellular adhesion, whilst damaged respiratory epithelium is the primary instigato...