Restricted TcR β chain CDR3 clonotype is associated with resolved acute hepatitis B subjects

• Published in: BMC infectious diseases Vol. 21; no. 1; pp. 111 - 11
• Main Authors: Xiao, Dangsheng, Wang, Ju, Chen, Zhitao, Jin, Xiuyuan, Xie, Yirui, Yan, Dong, Yang, Jiezuan
• Format: Journal Article
• Language: English
• Published: England BioMed Central 23.01.2021; BMC
• Subjects: Adult; Antibodies; Antigens; Chains; Cloning; Complementarity Determining Regions - genetics; Complementarity-determining region 3; Deoxyribonucleic acid; DNA; Enzymes; Female; Genotypes; HBsAg seroconversion; Hepatitis; Hepatitis B; Hepatitis B - blood; Hepatitis B - immunology; Hepatitis B Antibodies - blood; Hepatitis B surface antigen; Hepatitis B Surface Antigens - blood; Hepatitis B virus - immunology; Hepatitis B, Chronic - genetics; Hepatitis B, Chronic - immunology; High throughput sequencing; High-Throughput Nucleotide Sequencing; Humans; Infections; Infectious diseases; Laboratories; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Liver; Lymphocytes; Lymphocytes T; Male; Middle Aged; Next-generation sequencing; Peripheral blood mononuclear cells; Receptors, Antigen, T-Cell, alpha-beta - genetics; Resolved acute hepatitis B; Seroconversion; Serology; T cell receptor; T cell receptors; T-Lymphocytes - immunology; Variable region; Young Adult; United States > US; China; Resolved acute hepatitis B; T cell receptor; High throughput sequencing; HBsAg seroconversion; Complementarity-determining region 3
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-021-05816-2

T cells play an important role in the prognosis of hepatitis B virus (HBV) infection, and are involved in the seroconversion of a patient from HBsAb negative to positive. To compare the T-cell receptor β-chain variable region (TcRBV) complementarity-determining region 3 (CDR3) in subjects with or wi...