CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases

• Published in: Frontiers in immunology Vol. 8; p. 1216
• Main Authors: Le Gallo, Matthieu, Poissonnier, Amanda, Blanco, Patrick, Legembre, Patrick
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 27.09.2017; Frontiers Media S.A
• Subjects: apoptosis; Cancer; Chemical Sciences; endothelium; Fas; FasL; Immunology; Life Sciences; lupus metastasis; migration; endothelium; FasL; tyrosine kinase; migration; Fas; apoptosis; lupus metastasis

Endothelial cells lining new blood vessels that develop during inflammatory disorders or cancers act as doors that either allow or block access to the tumor or inflamed organ. Recent data show that these endothelial cells in cancer tissues and inflamed tissues of lupus patients overexpress CD95L, th...