Regulation of transcription and chromatin structure by pRB: Here, there and everywhere

• Published in: Cell cycle (Georgetown, Tex.) Vol. 11; no. 17; pp. 3189 - 3198
• Main Authors: Talluri, Srikanth, Dick, Frederick A.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.09.2012; Landes Bioscience
• Subjects: Binding; Biology; Bioscience; Calcium; Cancer; Cell; cell cycle; Cell Cycle Checkpoints - genetics; Cell Cycle Checkpoints - physiology; Cellular Senescence - physiology; chromatin; Chromatin Assembly and Disassembly - physiology; condensin; Cycle; differentiation; E2F; Gene Expression Regulation - physiology; Genes, cdc - physiology; Landes; Models, Biological; Organogenesis; Promoter Regions, Genetic - physiology; Proteins; retinoblastoma; Retinoblastoma Protein - metabolism; Retinoblastoma Protein - physiology; Review; senescence; Signal Transduction - physiology; transcription; Transcription, Genetic - physiology

Commitment to divide is one of the most crucial steps in the mammalian cell division cycle. It is critical for tissue and organismal homeostasis, and consequently is highly regulated. The vast majority of cancers evade proliferative control, further emphasizing the importance of the commitment step...