Regulation of transcription and chromatin structure by pRB: Here, there and everywhere

Commitment to divide is one of the most crucial steps in the mammalian cell division cycle. It is critical for tissue and organismal homeostasis, and consequently is highly regulated. The vast majority of cancers evade proliferative control, further emphasizing the importance of the commitment step...

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Published inCell cycle (Georgetown, Tex.) Vol. 11; no. 17; pp. 3189 - 3198
Main Authors Talluri, Srikanth, Dick, Frederick A.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.09.2012
Landes Bioscience
Subjects
Binding
Biology
Bioscience
Calcium
Cancer
Cell
cell cycle
Cell Cycle Checkpoints - genetics
Cell Cycle Checkpoints - physiology
Cellular Senescence - physiology
chromatin
Chromatin Assembly and Disassembly - physiology
condensin
Cycle
differentiation
E2F
Gene Expression Regulation - physiology
Genes, cdc - physiology
Landes
Models, Biological
Organogenesis
Promoter Regions, Genetic - physiology
Proteins
retinoblastoma
Retinoblastoma Protein - metabolism
Retinoblastoma Protein - physiology
Review
senescence
Signal Transduction - physiology
transcription
Transcription, Genetic - physiology
Online AccessGet full text
ISSN1538-4101
1551-4005
1551-4005
DOI10.4161/cc.21263

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Abstract Commitment to divide is one of the most crucial steps in the mammalian cell division cycle. It is critical for tissue and organismal homeostasis, and consequently is highly regulated. The vast majority of cancers evade proliferative control, further emphasizing the importance of the commitment step in cell cycle regulation. The Retinoblastoma (RB) tumor suppressor pathway regulates this decision-making step. Since being the subject of Knudson's 'two hit hypothesis', there has been considerable interest in understanding pRB's role in cancer. It is best known for repressing E2F dependent transcription of cell cycle genes. However, pRB's role in controlling chromatin structure is expanding and bringing it into new regulatory paradigms. In this review we discuss pRB function through protein-protein interactions, at the level of transcriptional regulation of individual promoters and in organizing higher order chromatin domains.
AbstractList Commitment to divide is one of the most crucial steps in the mammalian cell division cycle. It is critical for tissue and organismal homeostasis, and consequently is highly regulated. The vast majority of cancers evade proliferative control, further emphasizing the importance of the commitment step in cell cycle regulation. The Retinoblastoma (RB) tumor suppressor pathway regulates this decision-making step. Since being the subject of Knudson's 'two hit hypothesis', there has been considerable interest in understanding pRB's role in cancer. It is best known for repressing E2F dependent transcription of cell cycle genes. However, pRB's role in controlling chromatin structure is expanding and bringing it into new regulatory paradigms. In this review we discuss pRB function through protein-protein interactions, at the level of transcriptional regulation of individual promoters and in organizing higher order chromatin domains.
Commitment to divide is one of the most crucial steps in the mammalian cell division cycle. It is critical for tissue and organismal homeostasis, and consequently is highly regulated. The vast majority of cancers evade proliferative control, further emphasizing the importance of the commitment step in cell cycle regulation. The Retinoblastoma (RB) tumor suppressor pathway regulates this decision-making step. Since being the subject of Knudson's 'two hit hypothesis', there has been considerable interest in understanding pRB's role in cancer. It is best known for repressing E2F dependent transcription of cell cycle genes. However, pRB's role in controlling chromatin structure is expanding and bringing it into new regulatory paradigms. In this review we discuss pRB function through protein-protein interactions, at the level of transcriptional regulation of individual promoters and in organizing higher order chromatin domains.Commitment to divide is one of the most crucial steps in the mammalian cell division cycle. It is critical for tissue and organismal homeostasis, and consequently is highly regulated. The vast majority of cancers evade proliferative control, further emphasizing the importance of the commitment step in cell cycle regulation. The Retinoblastoma (RB) tumor suppressor pathway regulates this decision-making step. Since being the subject of Knudson's 'two hit hypothesis', there has been considerable interest in understanding pRB's role in cancer. It is best known for repressing E2F dependent transcription of cell cycle genes. However, pRB's role in controlling chromatin structure is expanding and bringing it into new regulatory paradigms. In this review we discuss pRB function through protein-protein interactions, at the level of transcriptional regulation of individual promoters and in organizing higher order chromatin domains.
Author Dick, Frederick A.
Talluri, Srikanth
AuthorAffiliation London Regional Cancer Program; Western University; London, ON Canada
Children’s Health Research Institute; Western University; London, ON Canada
Department of Biochemistry; Western University; London, ON Canada
AuthorAffiliation_xml – name: Department of Biochemistry; Western University; London, ON Canada
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/22895179$$D View this record in MEDLINE/PubMed
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Snippet Commitment to divide is one of the most crucial steps in the mammalian cell division cycle. It is critical for tissue and organismal homeostasis, and...
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landesbioscience
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StartPage 3189
SubjectTerms Binding
Biology
Bioscience
Calcium
Cancer
Cell
cell cycle
Cell Cycle Checkpoints - genetics
Cell Cycle Checkpoints - physiology
Cellular Senescence - physiology
chromatin
Chromatin Assembly and Disassembly - physiology
condensin
Cycle
differentiation
E2F
Gene Expression Regulation - physiology
Genes, cdc - physiology
Landes
Models, Biological
Organogenesis
Promoter Regions, Genetic - physiology
Proteins
retinoblastoma
Retinoblastoma Protein - metabolism
Retinoblastoma Protein - physiology
Review
senescence
Signal Transduction - physiology
transcription
Transcription, Genetic - physiology
Title Regulation of transcription and chromatin structure by pRB: Here, there and everywhere
URI https://www.tandfonline.com/doi/abs/10.4161/cc.21263
http://www.landesbioscience.com/journals/cc/article/21263/
https://www.ncbi.nlm.nih.gov/pubmed/22895179
https://www.proquest.com/docview/1039883438
https://pubmed.ncbi.nlm.nih.gov/PMC3466518
Volume 11
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