peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids

• Published in: The FASEB journal Vol. 21; no. 1; pp. 99 - 107
• Main Authors: Reilly, Sarah-Jayne, O'Shea, Ethna M, Andersson, Ulla, O'Byrne, James, Alexson, Stefan E.H, Hunt, Mary C
• Format: Journal Article
• Language: English
• Published: United States The Federation of American Societies for Experimental Biology 2007
• Subjects: Acyltransferases - chemistry; Acyltransferases - genetics; Acyltransferases - metabolism; Amino Acid Sequence; Animals; Base Sequence; DNA Primers; Fatty Acids - metabolism; Male; Mice; Molecular Sequence Data; Peroxisomes - enzymology; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Spectrometry, Mass, Electrospray Ionization; Taurine - metabolism

A wide variety of endogenous carboxylic acids and xenobiotics are conjugated with amino acids, before excretion in urine or bile. The conjugation of carboxylic acids and bile acids with taurine and glycine has been widely characterized, and de novo synthesized bile acids are conjugated to either gly...