Recent advances in intestinal smooth muscle research: from muscle strips and single cells, via ICC networks to whole organ physiology and assessment of human gut motor dysfunction

• Published in: Journal of Smooth Muscle Research Vol. 55; pp. 68 - 80
• Main Author: Huizinga, Jan D.
• Format: Journal Article
• Language: English
• Published: Japan Japan Society of Smooth Muscle Research 2019
• Subjects: Biomedical Research; dysmotility; Enteric Nervous System - metabolism; Enteric Nervous System - pathology; Enteric Nervous System - physiopathology; Gastrointestinal Motility; high-resolution manometry; Humans; interstitial cells of Cajal; Intestinal Diseases - metabolism; Intestinal Diseases - pathology; Intestinal Diseases - physiopathology; Invited Review; Muscle, Smooth - metabolism; Muscle, Smooth - pathology; Muscle, Smooth - physiopathology; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; spatiotemporal mapping; gastrointestinal motility; high-resolution manometry; spatiotemporal mapping; dysmotility; interstitial cells of Cajal

Gastrointestinal smooth muscle research has evolved from studies on muscle strips to spatiotemporal mapping of whole organ motor and electrical activities. Decades of research on single muscle cells and small sections of isolated musculature from animal models has given us the groundwork for interpr...