Recent advances in intestinal smooth muscle research: from muscle strips and single cells, via ICC networks to whole organ physiology and assessment of human gut motor dysfunction

Gastrointestinal smooth muscle research has evolved from studies on muscle strips to spatiotemporal mapping of whole organ motor and electrical activities. Decades of research on single muscle cells and small sections of isolated musculature from animal models has given us the groundwork for interpr...

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Published inJournal of Smooth Muscle Research Vol. 55; pp. 68 - 80
Main Author Huizinga, Jan D.
Format Journal Article
LanguageEnglish
Published Japan Japan Society of Smooth Muscle Research 2019
Subjects
Biomedical Research
dysmotility
Enteric Nervous System - metabolism
Enteric Nervous System - pathology
Enteric Nervous System - physiopathology
Gastrointestinal Motility
high-resolution manometry
Humans
interstitial cells of Cajal
Intestinal Diseases - metabolism
Intestinal Diseases - pathology
Intestinal Diseases - physiopathology
Invited Review
Muscle, Smooth - metabolism
Muscle, Smooth - pathology
Muscle, Smooth - physiopathology
Myocytes, Smooth Muscle - metabolism
Myocytes, Smooth Muscle - pathology
spatiotemporal mapping
gastrointestinal motility
high-resolution manometry
spatiotemporal mapping
dysmotility
interstitial cells of Cajal
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Abstract Gastrointestinal smooth muscle research has evolved from studies on muscle strips to spatiotemporal mapping of whole organ motor and electrical activities. Decades of research on single muscle cells and small sections of isolated musculature from animal models has given us the groundwork for interpretation of human in vivo studies. Human gut motility studies have dramatically improved by high-resolution manometry and high-resolution electrophysiology. The details that emerge from spatiotemporal mapping of high-resolution data are now of such quality that hypotheses can be generated as to the physiology (in healthy subjects) and pathophysiology (in patients) of gastrointestinal (dys) motility. Such interpretation demands understanding of the musculature as a super-network of excitable cells (neurons, smooth muscle cells, other accessory cells) and oscillatory cells (the pacemaker interstitial cells of Cajal), for which mathematical modeling becomes essential. The developing deeper understanding of gastrointestinal motility will bring us soon to a level of precision in diagnosis of dysfunction that is far beyond what is currently available.
AbstractList Gastrointestinal smooth muscle research has evolved from studies on muscle strips to spatiotemporal mapping of whole organ motor and electrical activities. Decades of research on single muscle cells and small sections of isolated musculature from animal models has given us the groundwork for interpretation of human in vivo studies. Human gut motility studies have dramatically improved by high-resolution manometry and high-resolution electrophysiology. The details that emerge from spatiotemporal mapping of high-resolution data are now of such quality that hypotheses can be generated as to the physiology (in healthy subjects) and pathophysiology (in patients) of gastrointestinal (dys) motility. Such interpretation demands understanding of the musculature as a super-network of excitable cells (neurons, smooth muscle cells, other accessory cells) and oscillatory cells (the pacemaker interstitial cells of Cajal), for which mathematical modeling becomes essential. The developing deeper understanding of gastrointestinal motility will bring us soon to a level of precision in diagnosis of dysfunction that is far beyond what is currently available.
Gastrointestinal smooth muscle research has evolved from studies on muscle strips to spatiotemporal mapping of whole organ motor and electrical activities. Decades of research on single muscle cells and small sections of isolated musculature from animal models has given us the groundwork for interpretation of human in vivo studies. Human gut motility studies have dramatically improved by high-resolution manometry and high-resolution electrophysiology. The details that emerge from spatiotemporal mapping of high-resolution data are now of such quality that hypotheses can be generated as to the physiology (in healthy subjects) and pathophysiology (in patients) of gastrointestinal (dys) motility. Such interpretation demands understanding of the musculature as a super-network of excitable cells (neurons, smooth muscle cells, other accessory cells) and oscillatory cells (the pacemaker interstitial cells of Cajal), for which mathematical modeling becomes essential. The developing deeper understanding of gastrointestinal motility will bring us soon to a level of precision in diagnosis of dysfunction that is far beyond what is currently available.
Author Huizinga, Jan D.
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Keywords gastrointestinal motility
high-resolution manometry
spatiotemporal mapping
dysmotility
interstitial cells of Cajal
Language English
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Snippet Gastrointestinal smooth muscle research has evolved from studies on muscle strips to spatiotemporal mapping of whole organ motor and electrical activities....
Gastrointestinal smooth muscle research has evolved from studies on muscle strips to spatiotemporal mapping of whole organ motor and electrical activities....
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SubjectTerms Biomedical Research
dysmotility
Enteric Nervous System - metabolism
Enteric Nervous System - pathology
Enteric Nervous System - physiopathology
Gastrointestinal Motility
high-resolution manometry
Humans
interstitial cells of Cajal
Intestinal Diseases - metabolism
Intestinal Diseases - pathology
Intestinal Diseases - physiopathology
Invited Review
Muscle, Smooth - metabolism
Muscle, Smooth - pathology
Muscle, Smooth - physiopathology
Myocytes, Smooth Muscle - metabolism
Myocytes, Smooth Muscle - pathology
spatiotemporal mapping
Title Recent advances in intestinal smooth muscle research: from muscle strips and single cells, via ICC networks to whole organ physiology and assessment of human gut motor dysfunction
URI https://www.jstage.jst.go.jp/article/jsmr/55/0/55_0505/_article/-char/en
https://www.ncbi.nlm.nih.gov/pubmed/31956167
https://pubmed.ncbi.nlm.nih.gov/PMC6962316
Volume 55
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