Accumulation and Changes in Composition of Collagens in Subcutaneous Adipose Tissue After Bariatric Surgery

• Published in: The journal of clinical endocrinology and metabolism Vol. 101; no. 1; pp. 293 - 304
• Main Authors: Liu, Yuejun, Aron-Wisnewsky, Judith, Marcelin, Geneviève, Genser, Laurent, Le Naour, Gilles, Torcivia, Adriana, Bauvois, Brigitte, Bouchet, Sandrine, Pelloux, Véronique, Sasso, Magali, Miette, Véronique, Tordjman, Joan, Clément, Karine
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.01.2016; Copyright by The Endocrine Society; Oxford University Press
• Subjects: Adipose tissue; Adult; Bariatric Surgery; Biopsy; Body Composition; Body fat; Body weight loss; CD163 antigen; Collagen; Collagen (type I); Collagen - metabolism; Cross-linking; Elasticity Imaging Techniques; Endocrinology and metabolism; Enzyme inhibitors; Enzymes; Extracellular matrix; Extracellular Matrix - metabolism; Extracellular Matrix Proteins - metabolism; Female; Gastrointestinal surgery; Human health and pathology; Humans; Life Sciences; Lysyl oxidase; Macrophages; Macrophages - metabolism; Male; Metabolism; Middle Aged; Obesity; Obesity, Morbid - metabolism; Obesity, Morbid - surgery; Physical characteristics; Subcutaneous Fat - metabolism; Surgery; Transcriptome; Transcriptomics; Vascular Stiffness; Weight Loss; weight loss; collagen accumulation; fibrosis; cross-linking; adipose tissue remodeling

Context:Extracellular matrix (ECM) in sc adipose tissue (scAT) undergoes pathological remodeling during obesity. However, its evolution during weight loss remains poorly explored.Objective:The objective of the investigation was to study the histological, transcriptomic, and physical characteristics...