Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation

• Published in: Journal of cellular physiology Vol. 204; no. 2; pp. 428 - 436
• Main Authors: Fredj, Sandra, Bescond, Jocelyn, Louault, Claire, Delwail, Adriana, Lecron, Jean-claude, Potreau, Daniel
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2005; Wiley
• Subjects: Angiotensin II - metabolism; Animals; Antigens, CD - metabolism; Cell Proliferation; Cells, Cultured; Cytokine Receptor gp130; Fibroblasts - metabolism; Fibroblasts - pathology; Hypertrophy; Interleukin-6 - biosynthesis; Interleukin-6 - metabolism; Interleukin-6 - physiology; Life Sciences; Membrane Glycoproteins - metabolism; Mice; Myocardium - metabolism; Myocardium - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Receptor, Angiotensin, Type 1 - metabolism; Tissue Distribution

The process of cardiac hypertrophy is considered to involve two components: that of cardiac myocyte (CM) enlargement and cardiac fibroblast (CF) proliferation. The interleukin‐6 (IL‐6) family cytokines have been implicated in a variety of cellular and molecular interactions between myocytes and non‐...