A Charge‐Switchable Zwitterionic Peptide for Rapid Detection of SARS‐CoV‐2 Main Protease

• Published in: Angewandte Chemie International Edition Vol. 61; no. 9; pp. e202112995 - n/a
• Main Authors: Jin, Zhicheng, Mantri, Yash, Retout, Maurice, Cheng, Yong, Zhou, Jiajing, Jorns, Alec, Fajtova, Pavla, Yim, Wonjun, Moore, Colman, Xu, Ming, Creyer, Matthew N., Borum, Raina M., Zhou, Jingcheng, Wu, Zhuohong, He, Tengyu, Penny, William F., O'Donoghue, Anthony J., Jokerst, Jesse V.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 21.02.2022
• Edition: International ed. in English
• Subjects: Biomarkers - metabolism; Breath Tests; Colloids; Colorimetric analysis; Colorimetry - methods; Coronavirus 3C Proteases - metabolism; Coronaviruses; COVID-19; COVID-19 - diagnosis; COVID-19 - virology; Humans; Life cycles; Limit of Detection; mpro/3clpro/nsp5; Nanoparticles; Nucleic acids; Pandemics; Peptides; Peptides - metabolism; Portable equipment; Protease; Proteinase; Proteolysis; SARS-CoV-2 - metabolism; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Smart mask; Substrates; Viral diseases; Zwitterionic peptide; Zwitterions; Smart mask; Covid-19; Colorimetric analysis; Zwitterionic peptide; mpro/3clpro/nsp5

The transmission of SARS‐CoV‐2 coronavirus has led to the COVID‐19 pandemic. Nucleic acid testing while specific has limitations for mass surveillance. One alternative is the main protease (Mpro) due to its functional importance in mediating the viral life cycle. Here, we describe a combination of m...