Role of the mechanotransductor PIEZO1 in megakaryocyte differentiation

• Published in: Journal of cellular and molecular medicine Vol. 28; no. 18; pp. e70055 - n/a
• Main Authors: Demagny, Julien, Poirault‐Chassac, Sonia, Ilsaint, Damtz Nehemie, Marchelli, Aurore, Gomila, Cathy, Ouled‐Haddou, Hakim, Collet, Louison, Le Guyader, Maïlys, Gaussem, Pascale, Garçon, Loïc, Bachelot‐Loza, Christilla
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.09.2024; Wiley Open Access; John Wiley and Sons Inc
• Subjects: Anemia, Hemolytic, Congenital - genetics; Anemia, Hemolytic, Congenital - metabolism; Anemia, Hemolytic, Congenital - pathology; Antigens, CD34 - metabolism; Automation; Blood; Blood Platelets - metabolism; Calcium - metabolism; Calcium influx; CD34 antigen; Cell activation; Cell culture; Cell differentiation; Cell Differentiation - genetics; Cell growth; Cell proliferation; Flow cytometry; Hematology; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - metabolism; Hemolytic anemia; Human health and pathology; Humans; Hydrops Fetalis - genetics; Hydrops Fetalis - metabolism; Hydrops Fetalis - pathology; Ion Channels - genetics; Ion Channels - metabolism; Life Sciences; Mechanical properties; Mechanotransduction, Cellular; Megakaryocytes; Megakaryocytes - cytology; Megakaryocytes - metabolism; Mortality; Mutation; Original; Phosphorylation; PIEZO1; proplatelet formation; Pyrazines; Shear stress; Thiadiazoles; Thrombopoiesis; Thrombopoiesis - genetics; proplatelet formation; PIEZO1; megakaryocytes

From haematopoietic stem cells to megakaryocytes (Mks), cells undergo various mechanical forces that affect Mk differentiation, maturation and proplatelet formation. The mechanotransductor PIEZO1 appears to be a natural candidate for sensing these mechanical forces and regulating megakaryopoiesis an...