α-Bisabolol Mitigates Colon Inflammation by Stimulating Colon PPAR-γ Transcription Factor: In Vivo and In Vitro Study

• Published in: PPAR research Vol. 2022; pp. 1 - 22
• Main Authors: Venkataraman, Balaji, Almarzooqi, Saeeda, Raj, Vishnu, Dudeja, Pradeep K., Bhongade, Bhoomendra A., Patil, Rajesh B., Ojha, Shreesh K., Attoub, Samir, Adrian, Thomas E., Subramanya, Sandeep B.
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2022; John Wiley & Sons, Inc; Wiley
• Subjects: Adenocarcinoma; Animals; Binding sites; Cancer; Cell culture; Chemokines; Colon; Colon cancer; Crohn's disease; Cyclooxygenase-2; Cytokines; Development and progression; Drug development; Dysbacteriosis; Environmental factors; Epithelium; Etiology; Gene expression; Hydrogen bonds; Immune response; Immunosuppressive agents; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Interleukin 1; Interleukin 6; Interleukin 8; Ligands; Lipopolysaccharides; Macrophages; MAP kinase; Molecular modelling; NF-κB protein; Peroxidase; Protein kinase; Protein kinases; Proteins; Simulation; Ulcerative colitis; Honduras; Illinois; United States > US

The incidence and prevalence of inflammatory bowel disease (IBD, Crohn’s disease, and ulcerative colitis) are increasing worldwide. The etiology of IBD is multifactorial, including genetic predisposition, dysregulated immune response, microbial dysbiosis, and environmental factors. However, many of...