Mechanisms of selection mediated by interleukin-7, the preBCR, and hemokinin-1 during B-cell development

• Published in: Immunological reviews Vol. 197; no. 1; pp. 75 - 88
• Main Authors: Milne, Craig D., Fleming, Heather E., Zhang, Yu, Paige, Christopher J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK; Malden , USA Blackwell Publishing Ltd/Inc 01.02.2004
• Subjects: Animals; B-Lymphocytes - cytology; B-Lymphocytes - immunology; Cell Differentiation; Cell Lineage; Humans; Interleukin-7 - physiology; Ligands; Lymphopoiesis; Mice; Mitogen-Activated Protein Kinases - physiology; Protein Precursors - physiology; Receptors, Antigen, B-Cell - physiology; Signal Transduction; Stem Cells - immunology; Stromal Cells - cytology; Tachykinins - physiology

Many of the stromal‐derived signals and factors that regulate B lymphopoiesis have been identified. We review recent evidence from our laboratory that shows that there are at least three phases during B‐cell development when cells direct their own maturation, independent of stromal cells. Following...