Association of Serum Phosphate with Efficacy of Statin Therapy in Hemodialysis Patients

• Published in: Clinical journal of the American Society of Nephrology Vol. 17; no. 4; pp. 546 - 554
• Main Authors: Massy, Ziad A., Merkling, Thomas, Wagner, Sandra, Girerd, Nicolas, Essig, Marie, Wanner, Christoph, Fellstrom, Bengt C., Rossignol, Patrick, Zannad, Faiez
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.04.2022
• Subjects: Cardiovascular Diseases - etiology; Cardiovascular Diseases - prevention & control; Cholesterol; dialysis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects; hyperphosphatemia; Life Sciences; Original; phosphate; Phosphates; Renal Dialysis - adverse effects; statins; dialysis; phosphate; cholesterol; hyperphosphatemia; statins

Visual Abstract Background and objectives Statins are less efficacious in reducing cardiovascular disease risk in patients on dialysis than in the general population. Recent experimental data showed that phosphate excess promotes cellular de novo cholesterol synthesis through 3-hydroxy-3-methylgluta...