Effect of Early Rehabilitation in the Intensive Care Unit by a Dedicated Therapist Using a Rehabilitation Protocol: A Single-center Retrospective Study

Objectives: This study investigated retrospectively the effect of early rehabilitation in the intensive care unit (ICU) by a dedicated therapist using a rehabilitation protocol.Methods: The subjects comprised patients admitted to our emergency ICU. A dedicated therapist and a rehabilitation protocol...

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Published inProgress in Rehabilitation Medicine Vol. 6; p. 20210030
Main Authors Sakai, Kazutaka, Tsujita, Yasuyuki, Iwai, Kohji, Torimoto, Mayu, Hisano, Tomoyuki, Komada, Ryo, Miyai, Tamami
Format Journal Article
LanguageEnglish
Published The Japanese Association of Rehabilitation Medicine 01.01.2021
JARM
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ISSN2432-1354
2432-1354
DOI10.2490/prm.20210030

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Abstract Objectives: This study investigated retrospectively the effect of early rehabilitation in the intensive care unit (ICU) by a dedicated therapist using a rehabilitation protocol.Methods: The subjects comprised patients admitted to our emergency ICU. A dedicated therapist and a rehabilitation protocol were instigated in April 2018. We enrolled 330 patients in phase I (April 2016–March 2018) and 383 patients in phase II (April 2018–March 2020). Patients in the ICU for only one night and pediatric patients were excluded. The following data were accessed from medical records: sex, height, age, Sequential Organ Failure Assessment, rehabilitation intervention, ventilation at admission, duration of mechanical ventilation, extubation, reintubation, tracheotomy, length of ICU stay, length of hospital stay, and outcome. The effectiveness of rehabilitation was assessed using the time from ICU admission to the first rehabilitation session, first sitting exercise, and first standing exercise. Clinical outcomes were analyzed separately for subjects discharged to home or transferred to another hospital.Results: The percentage of subjects undergoing rehabilitation intervention increased significantly from 23.4% to 56.7% (P<0.001) in phase II. Moreover, reintubation (P=0.045); the length of ICU stay (P=0.022); and the time from ICU admission to the first rehabilitation session (P<0.001), the first sitting exercise (P=0.001), and the first standing exercise (P=0.047) significantly decreased in phase II. Furthermore, the duration of mechanical ventilation (P=0.007) and the length of ICU stay (P=0.036) were significantly reduced in the transfer group.Conclusions: Although the effectiveness of early intervention was suggested, prospective multicenter studies are required to confirm this finding.
AbstractList Objectives: This study investigated retrospectively the effect of early rehabilitation in the intensive care unit (ICU) by a dedicated therapist using a rehabilitation protocol.Methods: The subjects comprised patients admitted to our emergency ICU. A dedicated therapist and a rehabilitation protocol were instigated in April 2018. We enrolled 330 patients in phase I (April 2016–March 2018) and 383 patients in phase II (April 2018–March 2020). Patients in the ICU for only one night and pediatric patients were excluded. The following data were accessed from medical records: sex, height, age, Sequential Organ Failure Assessment, rehabilitation intervention, ventilation at admission, duration of mechanical ventilation, extubation, reintubation, tracheotomy, length of ICU stay, length of hospital stay, and outcome. The effectiveness of rehabilitation was assessed using the time from ICU admission to the first rehabilitation session, first sitting exercise, and first standing exercise. Clinical outcomes were analyzed separately for subjects discharged to home or transferred to another hospital.Results: The percentage of subjects undergoing rehabilitation intervention increased significantly from 23.4% to 56.7% (P<0.001) in phase II. Moreover, reintubation (P=0.045); the length of ICU stay (P=0.022); and the time from ICU admission to the first rehabilitation session (P<0.001), the first sitting exercise (P=0.001), and the first standing exercise (P=0.047) significantly decreased in phase II. Furthermore, the duration of mechanical ventilation (P=0.007) and the length of ICU stay (P=0.036) were significantly reduced in the transfer group.Conclusions: Although the effectiveness of early intervention was suggested, prospective multicenter studies are required to confirm this finding.
This study investigated retrospectively the effect of early rehabilitation in the intensive care unit (ICU) by a dedicated therapist using a rehabilitation protocol.OBJECTIVESThis study investigated retrospectively the effect of early rehabilitation in the intensive care unit (ICU) by a dedicated therapist using a rehabilitation protocol.The subjects comprised patients admitted to our emergency ICU. A dedicated therapist and a rehabilitation protocol were instigated in April 2018. We enrolled 330 patients in phase I (April 2016-March 2018) and 383 patients in phase II (April 2018-March 2020). Patients in the ICU for only one night and pediatric patients were excluded. The following data were accessed from medical records: sex, height, age, Sequential Organ Failure Assessment, rehabilitation intervention, ventilation at admission, duration of mechanical ventilation, extubation, reintubation, tracheotomy, length of ICU stay, length of hospital stay, and outcome. The effectiveness of rehabilitation was assessed using the time from ICU admission to the first rehabilitation session, first sitting exercise, and first standing exercise. Clinical outcomes were analyzed separately for subjects discharged to home or transferred to another hospital.METHODSThe subjects comprised patients admitted to our emergency ICU. A dedicated therapist and a rehabilitation protocol were instigated in April 2018. We enrolled 330 patients in phase I (April 2016-March 2018) and 383 patients in phase II (April 2018-March 2020). Patients in the ICU for only one night and pediatric patients were excluded. The following data were accessed from medical records: sex, height, age, Sequential Organ Failure Assessment, rehabilitation intervention, ventilation at admission, duration of mechanical ventilation, extubation, reintubation, tracheotomy, length of ICU stay, length of hospital stay, and outcome. The effectiveness of rehabilitation was assessed using the time from ICU admission to the first rehabilitation session, first sitting exercise, and first standing exercise. Clinical outcomes were analyzed separately for subjects discharged to home or transferred to another hospital.The percentage of subjects undergoing rehabilitation intervention increased significantly from 23.4% to 56.7% (P<0.001) in phase II. Moreover, reintubation (P=0.045); the length of ICU stay (P=0.022); and the time from ICU admission to the first rehabilitation session (P<0.001), the first sitting exercise (P=0.001), and the first standing exercise (P=0.047) significantly decreased in phase II. Furthermore, the duration of mechanical ventilation (P=0.007) and the length of ICU stay (P=0.036) were significantly reduced in the transfer group.RESULTSThe percentage of subjects undergoing rehabilitation intervention increased significantly from 23.4% to 56.7% (P<0.001) in phase II. Moreover, reintubation (P=0.045); the length of ICU stay (P=0.022); and the time from ICU admission to the first rehabilitation session (P<0.001), the first sitting exercise (P=0.001), and the first standing exercise (P=0.047) significantly decreased in phase II. Furthermore, the duration of mechanical ventilation (P=0.007) and the length of ICU stay (P=0.036) were significantly reduced in the transfer group.Although the effectiveness of early intervention was suggested, prospective multicenter studies are required to confirm this finding.CONCLUSIONSAlthough the effectiveness of early intervention was suggested, prospective multicenter studies are required to confirm this finding.
ArticleNumber 20210030
Author Komada, Ryo
Tsujita, Yasuyuki
Hisano, Tomoyuki
Sakai, Kazutaka
Miyai, Tamami
Torimoto, Mayu
Iwai, Kohji
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  fullname: Tsujita, Yasuyuki
  organization: Department of Critical and Intensive Care Medicine, Shiga University of Medical Science, Otsu, Japan
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  fullname: Iwai, Kohji
  organization: Division of Physical Therapy, Rehabilitation Units, Shiga University of Medical Science, Otsu, Japan
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  fullname: Torimoto, Mayu
  organization: Division of Physical Therapy, Rehabilitation Units, Shiga University of Medical Science, Otsu, Japan
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  fullname: Hisano, Tomoyuki
  organization: Division of Physical Therapy, Rehabilitation Units, Shiga University of Medical Science, Otsu, Japan
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  fullname: Komada, Ryo
  organization: Division of Physical Therapy, Rehabilitation Units, Shiga University of Medical Science, Otsu, Japan
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  organization: Division of Physical Therapy, Rehabilitation Units, Shiga University of Medical Science, Otsu, Japan
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crossref_primary_10_1111_nicc_13143
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Cites_doi 10.1186/s40560-016-0190-z
10.1097/CCM.0000000000003259
10.1007/s001340051292
10.2490/prm.20200027
10.1016/S0140-6736(09)60658-9
10.1136/thoraxjnl-2016-209858
10.1152/physrev.90100.2007
10.1155/2018/3654251
10.1371/journal.pone.0224565
10.1097/CCM.0000000000004382
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10.1001/jama.2013.278481
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10.1056/NEJM200005183422002
10.5847/wjem.j.issn.1920-8642.2014.01.008
10.1183/09031936.00010206
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9. Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T: Weaning from mechanical ventilation. Eur Respir J 2007;29:1033–1056. PMID:17470624, DOI:10.1183/09031936.00010206
21. Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP: Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009;373:1874–1882. PMID:19446324, DOI:10.1016/S0140-6736(09)60658-9
8. Matsuki R, Kojima N, Watanabe K, Hotta A, Kubori Y, Oura K, Morisawa T, Koyama H, Ebisu T, Hashino T: Impact of a rehabilitation protocol and a dedicated therapist in the intensive care unit on physical function and activities of daily living. Prog Rehabil Med 2020. doi: DOI:10.2490/prm.20200027
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18. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson NS, Padhke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M, Edwards LM, Smith K, Rowlerson A, Rennie MJ, Moxham J, Harridge SD, Hart N, Montgomery HE: Acute skeletal muscle wasting in critical illness. JAMA 2013;310:1591–1600. PMID:24108501, DOI:10.1001/jama.2013.278481
2. Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJ, Pandharipande PP, Watson PL, Weinhouse GL, Nunnally ME, Rochwerg B, Balas MC, van den Boogaard M, Bosma KJ, Brummel NE, Chanques G, Denehy L, Drouot X, Fraser GL, Harris JE, Joffe AM, Kho ME, Kress JP, Lanphere JA, McKinley S, Neufeld KJ, Pisani MA, Payen JF, Pun BT, Puntillo KA, Riker RR, Robinson BR, Shehabi Y, Szumita PM, Winkelman C, Centofanti JE, Price C, Nikayin S, Misak CJ, Flood PD, Kiedrowski K, Alhazzani W: Executive summary: clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 2018;46:1532–1548. PMID:30113371, DOI:10.1097/CCM.0000000000003259
13. Yosef-Brauner O, Adi N, Ben Shahar T, Yehezkel E, Carmeli E: Effect of physical therapy on muscle strength, respiratory muscles and functional parameters in patients with intensive care unit-acquired weakness. Clin Respir J 2015;9:1–6. PMID:24345055, DOI:10.1111/crj.12091
14. Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL: The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med 2017;43:171–183. PMID:27864615, DOI:10.1007/s00134-016-4612-0
12. Dong Z, Yu B, Sun Y, Fang W, Li L: Effects of early rehabilitation therapy on patients with mechanical ventilation. World J Emerg Med 2014;5:48–52. PMID:25215147, DOI:10.5847/wjem.j.issn.1920-8642.2014.01.008
20. Pedersen BK, Febbraio MA: Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 2008;88:1379–1406. PMID:18923185, DOI:10.1152/physrev.90100.2007
15. Waldauf P, Jiroutková K, Krajčová A, Puthucheary Z, Duška F: Effects of rehabilitation interventions on clinical outcomes in critically ill patients: systematic review and meta-analysis of randomized controlled trials. Crit Care Med 2020;48:1055–1065.
19. Wandrag L, Brett SJ, Frost GS, Bountziouka V, Hickson M: Exploration of muscle loss and metabolic state during prolonged critical illness: implications for intervention? PLoS One 2019;14:e0224565. PMID:31725748, DOI:10.1371/journal.pone.0224565
11. Fujii E, Fujino K, Tanaka-Mizuno S, Eguchi Y: Variation of risk factors for cause-specific reintubation: a preliminary study. Can Respir J 2018;2018:1–6. PMID:30510604, DOI:10.1155/2018/3654251
4. Pang Y, Li H, Zhao L, Zhang C: An established early rehabilitation therapy demonstrating higher efficacy and safety for care of intensive care unit patients. Med Sci Monit 2019;25:7052–7058. PMID:31537777, DOI:10.12659/MSM.916210
5. Schefold JC, Bierbrauer J, Weber-Carstens S: Intensive care unit-acquired weakness (ICUAW) and muscle wasting in critically ill patients with severe sepsis and septic shock. J Cachexia Sarcopenia Muscle 2010;1:147–157. PMID:21475702, DOI:10.1007/s13539-010-0010-6
1. Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogué S, Ferrer M: Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 1999;354:1851–1858. PMID:10584721, DOI:10.1016/S0140-6736(98)12251-1
3. Kress JP, Pohlman AS, O’Connor MF, Hall JB: Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471–1477. PMID:10816184, DOI:10.1056/NEJM200005183422002
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6. Norrenberg M, Vincent JL European Society of Intensive Care Medicine: A profile of European intensive care unit physiotherapists. Intensive Care Med 2000;26:988–994. PMID:10990117, DOI:10.1007/s001340051292
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References_xml – reference: 3. Kress JP, Pohlman AS, O’Connor MF, Hall JB: Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471–1477. PMID:10816184, DOI:10.1056/NEJM200005183422002
– reference: 7. Taito S, Sanui M, Yasuda H, Shime N, Lefor AK, Japanese Society of Education for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group: Current rehabilitation practices in intensive care units: a preliminary survey by the Japanese Society of Education for Physicians and Trainees in Intensive Care (JSEPTIC) Clinical Trial Group. J Intensive Care 2016;4:66. PMID:27800164, DOI:10.1186/s40560-016-0190-z
– reference: 4. Pang Y, Li H, Zhao L, Zhang C: An established early rehabilitation therapy demonstrating higher efficacy and safety for care of intensive care unit patients. Med Sci Monit 2019;25:7052–7058. PMID:31537777, DOI:10.12659/MSM.916210
– reference: 12. Dong Z, Yu B, Sun Y, Fang W, Li L: Effects of early rehabilitation therapy on patients with mechanical ventilation. World J Emerg Med 2014;5:48–52. PMID:25215147, DOI:10.5847/wjem.j.issn.1920-8642.2014.01.008
– reference: 14. Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL: The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med 2017;43:171–183. PMID:27864615, DOI:10.1007/s00134-016-4612-0
– reference: 9. Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T: Weaning from mechanical ventilation. Eur Respir J 2007;29:1033–1056. PMID:17470624, DOI:10.1183/09031936.00010206
– reference: 15. Waldauf P, Jiroutková K, Krajčová A, Puthucheary Z, Duška F: Effects of rehabilitation interventions on clinical outcomes in critically ill patients: systematic review and meta-analysis of randomized controlled trials. Crit Care Med 2020;48:1055–1065.
– reference: 20. Pedersen BK, Febbraio MA: Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 2008;88:1379–1406. PMID:18923185, DOI:10.1152/physrev.90100.2007
– reference: 1. Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogué S, Ferrer M: Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 1999;354:1851–1858. PMID:10584721, DOI:10.1016/S0140-6736(98)12251-1
– reference: 2. Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJ, Pandharipande PP, Watson PL, Weinhouse GL, Nunnally ME, Rochwerg B, Balas MC, van den Boogaard M, Bosma KJ, Brummel NE, Chanques G, Denehy L, Drouot X, Fraser GL, Harris JE, Joffe AM, Kho ME, Kress JP, Lanphere JA, McKinley S, Neufeld KJ, Pisani MA, Payen JF, Pun BT, Puntillo KA, Riker RR, Robinson BR, Shehabi Y, Szumita PM, Winkelman C, Centofanti JE, Price C, Nikayin S, Misak CJ, Flood PD, Kiedrowski K, Alhazzani W: Executive summary: clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 2018;46:1532–1548. PMID:30113371, DOI:10.1097/CCM.0000000000003259
– reference: 21. Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP: Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 2009;373:1874–1882. PMID:19446324, DOI:10.1016/S0140-6736(09)60658-9
– reference: 13. Yosef-Brauner O, Adi N, Ben Shahar T, Yehezkel E, Carmeli E: Effect of physical therapy on muscle strength, respiratory muscles and functional parameters in patients with intensive care unit-acquired weakness. Clin Respir J 2015;9:1–6. PMID:24345055, DOI:10.1111/crj.12091
– reference: 17. Ahn JY, Song JE, Ann HW, Jeon Y, Ahn MY, Jung IY, Kim MH, Jeong W, Jeong SJ, Ku NS, Kim JM, Na S, Cho SR, Choi JY: Effects of early exercise rehabilitation on functional recovery in patients with severe sepsis. Yonsei Med J 2018;59:843–851. PMID:30091317, DOI:10.3349/ymj.2018.59.7.843
– reference: 10. Thille AW, Richard JC, Brochard L: The decision to extubate in the intensive care unit. Am J Respir Crit Care Med 2013;187:1294–1302. PMID:23641924, DOI:10.1164/rccm.201208-1523CI
– reference: 6. Norrenberg M, Vincent JL European Society of Intensive Care Medicine: A profile of European intensive care unit physiotherapists. Intensive Care Med 2000;26:988–994. PMID:10990117, DOI:10.1007/s001340051292
– reference: 8. Matsuki R, Kojima N, Watanabe K, Hotta A, Kubori Y, Oura K, Morisawa T, Koyama H, Ebisu T, Hashino T: Impact of a rehabilitation protocol and a dedicated therapist in the intensive care unit on physical function and activities of daily living. Prog Rehabil Med 2020. doi: DOI:10.2490/prm.20200027
– reference: 18. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson NS, Padhke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M, Edwards LM, Smith K, Rowlerson A, Rennie MJ, Moxham J, Harridge SD, Hart N, Montgomery HE: Acute skeletal muscle wasting in critical illness. JAMA 2013;310:1591–1600. PMID:24108501, DOI:10.1001/jama.2013.278481
– reference: 5. Schefold JC, Bierbrauer J, Weber-Carstens S: Intensive care unit-acquired weakness (ICUAW) and muscle wasting in critically ill patients with severe sepsis and septic shock. J Cachexia Sarcopenia Muscle 2010;1:147–157. PMID:21475702, DOI:10.1007/s13539-010-0010-6
– reference: 16. Wright SE, Thomas K, Watson G, Baker C, Bryant A, Chadwick TJ, Shen J, Wood R, Wilkinson J, Mansfield L, Stafford V, Wade C, Furneval J, Henderson A, Hugill K, Howard P, Roy A, Bonner S, Baudouin S: Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial. Thorax 2018;73:213–221. PMID:28780504, DOI:10.1136/thoraxjnl-2016-209858
– reference: 19. Wandrag L, Brett SJ, Frost GS, Bountziouka V, Hickson M: Exploration of muscle loss and metabolic state during prolonged critical illness: implications for intervention? PLoS One 2019;14:e0224565. PMID:31725748, DOI:10.1371/journal.pone.0224565
– reference: 11. Fujii E, Fujino K, Tanaka-Mizuno S, Eguchi Y: Variation of risk factors for cause-specific reintubation: a preliminary study. Can Respir J 2018;2018:1–6. PMID:30510604, DOI:10.1155/2018/3654251
– ident: 7
  doi: 10.1186/s40560-016-0190-z
– ident: 2
  doi: 10.1097/CCM.0000000000003259
– ident: 6
  doi: 10.1007/s001340051292
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Snippet Objectives: This study investigated retrospectively the effect of early rehabilitation in the intensive care unit (ICU) by a dedicated therapist using a...
This study investigated retrospectively the effect of early rehabilitation in the intensive care unit (ICU) by a dedicated therapist using a rehabilitation...
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StartPage 20210030
SubjectTerms dedicated therapist
early rehabilitation
intensive care unit
Original
rehabilitation protocol
retrospective study
Title Effect of Early Rehabilitation in the Intensive Care Unit by a Dedicated Therapist Using a Rehabilitation Protocol: A Single-center Retrospective Study
URI https://www.jstage.jst.go.jp/article/prm/6/0/6_20210030/_article/-char/en
https://www.proquest.com/docview/2561910969
https://pubmed.ncbi.nlm.nih.gov/PMC8328794
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