Thrombomodulin expression by human keratinocytes : induction of cofactor activity during epidermal differentiation

• Published in: The Journal of clinical investigation Vol. 93; no. 4; pp. 1846 - 1851
• Main Authors: RAIFE, T. J, LAGER, D. J, MADISON, K. C, PIETTE, W. W, HOWARD, E. J, STURM, M. T, YAN CHEN, LENTZ, S. R
• Format: Journal Article
• Language: English
• Published: Ann Arbor, MI American Society for Clinical Investigation 01.04.1994
• Subjects: Biological and medical sciences; Cell Differentiation; Cells, Cultured; Epidermis - cytology; Epidermis - metabolism; Fundamental and applied biological sciences. Psychology; Gene expression; Humans; Keratinocytes - metabolism; Molecular and cellular biology; Molecular genetics; Protein C - metabolism; RNA, Messenger - analysis; Skin Neoplasms - metabolism; Thrombomodulin - biosynthesis; Thrombomodulin - genetics; Human; Cell culture; Epidermis; Keratinocyte; Skin; Cell differentiation; Gene expression; Thrombomodulin; Tumor cell

Thrombomodulin is an endothelial cell surface glycoprotein that inhibits the procoagulant activities of thrombin and accelerates activation of the anticoagulant protein C. Because protein C deficiency is associated with cutaneous thrombosis, we investigated the expression of thrombomodulin in human...