Dual role of nitroarenes as electrophiles and arylamine surrogates in Buchwald-Hartwig-type coupling for C-N bond construction

• Published in: Chemical science (Cambridge) Vol. 15; no. 1; pp. 3552 - 3561
• Main Authors: Lei, Zhiguo, Yao, Jiaxin, Xiao, Yuxuan, Liu, Wenbo H, Yu, Lin, Duan, Wengui, Li, Chao-Jun
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 06.03.2024; Royal Society of Chemistry; The Royal Society of Chemistry
• Subjects: Amines; Aromatic compounds; Chemistry; Chemistry, Multidisciplinary; Condensates; Cross coupling; Halides; Organic compounds; Physical Sciences; Science & Technology; Toxic wastes; Transition metals; AMIDATION; AMINATION; BEARING; HETEROCYCLES; LIGANDS; ESTERS

One of the most widely utilized methods for the construction of C(sp 2 )-N bonds is the transition-metal-catalyzed cross-coupling of aryl halides/boronic acids with amines, known as Ullmann condensation, Buchwald-Hartwig amination, and Chan-Lam coupling. However, aryl halides/boronic acids often req...