REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis

• Published in: Cell Vol. 121; no. 4; pp. 645 - 657
• Main Authors: Ballas, Nurit, Grunseich, Christopher, Lu, Diane D., Speh, Joan C., Mandel, Gail
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.05.2005
• Subjects: Animals; Cell Differentiation - genetics; Cells, Cultured; Chromatin - genetics; Chromatin - metabolism; DNA Methylation; DNA-Binding Proteins - metabolism; Gene Expression Regulation, Developmental - genetics; Genes, Regulator - genetics; Mice; Nerve Tissue Proteins - metabolism; Nervous System - embryology; Neuronal Plasticity - genetics; Neurons - metabolism; Pluripotent Stem Cells - metabolism; Repressor Proteins - genetics; Repressor Proteins - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism

Regulation of neuronal gene expression is critical to central nervous system development. Here, we show that REST regulates the transitions from pluripotent to neural stem/progenitor cell and from progenitor to mature neuron. In the transition to progenitor cell, REST is degraded to levels just suff...